血清HE4、NSE、CYFRA21-1水平变化对肺癌的诊断价值

目的探讨血清HE4、NSE、CYFRA21-1水平变化对肺癌的诊断价值。方法采用电化学发光法检测88例肺癌患者和70例肺良性疾病患者及50例健康对照者血清中的HE4、NSE、CYFRA21-1水平。结果肺癌组血清HE4、NSE、CYFRA21-1水平明显高于肺良性疾病组和健康对照组(P0.05);腺癌、鳞癌、小细胞肺癌分别以HE4、CYFRA21-1、N SE检测敏感性最高(P0.05);HE4、NSE、CYFRA21-1联合检测较单项检测诊断敏感性显著提高(P0.05)。结论 HE4、NSE、CYFRA21-1水平变化有助于肺癌的诊断和鉴别诊断,三项肿瘤标志物联合检测优于各项目单独检测。

Diagnostic value of serum HE4, NSE and CYFRA21-1 levels for lung cancer patients

Objective To investigate the diagnostic value of serum HE4, NSE and CYFRA21-1 levels for lung cancer. Methods The serum HE4, NSE and CYFRA21-1 levels in 88 patients with lung cancer and 70 pa-tients with benign lung disease patients and 50 healthy control was detected by using chemoluminescenee method. Re-sults The serum HE4, NSE and CYFRA21-1 levels in lung cancer were significantly higher than that in benign lung disease and the healthy control group (P<0. 05). The highest sensitivity of serum tumor markers in adencarcinoma, squamous cell carcinoma and small cell lung cancer was HE4, CYFRA21-1 and NSE respectively. Compared with each single item, the diagnostic sensitivity of the combined detection of HE4, NSE and CYFRA21-1 was greatly im-proved (P<0. 05). Conclusion The serum HE4, NSE and CYFRA21-1 levels contribute to the diagnosis and dif-ferential diagnosis of lung cancer, and the three combined detection of tumor markers is superior to each project indi-vidually tested.