无创正压通气对睡眠呼吸暂停综合征早期肾损害的疗效观察

目的观察无创正压通气(CPAP)治疗睡眠呼吸暂停综合症(OSAHS)早期肾损害敏感指标前后变化的临床意义。方法分析2013年8月至2014年10月在我院接受治疗的OSAHS早期肾损害患者(呼吸暂停低通气指数AHI≥5)的临床资料。根据是否采用CPAP治疗将入选者分成治疗组和对照组两组。比较两组患者的基线资料、治疗前后肾功能指标表达的变化及睡眠呼吸参数检查结果、ESS评分。结果本研究共纳入66例研究对象,其中治疗组和对照组各33例。两组患者的基线资料无统计学差异(P0.05)。治疗组治疗后的肾功能各指标水平明显低于对照组(P均0.05);两组患者治疗后各肾功能指标水平明显低于治疗前(P均0.05)。治疗组患者治疗前、后的睡眠呼吸参数检查结果以及ESS评分差异显著(P均0.05);且治疗后两组患者的睡眠呼吸参数检查结果以及ESS评分有统计学差异(P均0.05)。结论 CPAP治疗OSAHS早期肾损害患者的临床疗效显著,值得推广。

Observation of curative effect of CPAP in treatment of OSAHS patients with early kidney damage

Objective To analyze the clinical significance of CPAP in treatment of OSAHS patients with ear-ly renal injury. Methods The clinical data of OSAHS patients with early renal injury(AHI≥5)received treatment from August,2013 to October,2014 was retrospectively analyzed. Patients included were divided into two groups ac-cording to the treatment,the treatment group(CPAP training)and the control group(traditional combination thera-py). The general information and the changes of the expression of kidney indexes,the results of sleep respiratory pa-rameters,and ESS scores were compared between the two groups. Results A total of 66 patients were retrospective analyzed,including 33 in the observation group and 33 in the control group. The general information had no signifi-cant difference between the two groups. The levels of renal indexes were obviously lower in the treatment group than in the control group after treatment(P < 0. 05),and they were obviously lower than those before treatment(P <0. 05). The results of sleep respiratory parameters,and ESS scores had statistical difference before and after treat-ment in the treatment group(P < 0. 05),and they had statistical difference between the two groups after treatment(P< 0. 05). Conclusion The clinical efficacy of CPAP is significant in treatment of OSAHS patients with early renal injury,which is worthy of widely application.