| BRCA1在晚期非小细胞肺癌组织中的表达及预后意义 |
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| 引用本文： | 单莉,刘甚红,韩志刚. BRCA1在晚期非小细胞肺癌组织中的表达及预后意义[J]. 新疆医科大学学报, 2008, 31(12): 1724-1726 |
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| 作者姓名： | 单莉 刘甚红 韩志刚 |
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| 作者单位： | 1. 新疆医科大学附属肿瘤医院化疗一科,新疆,乌鲁木齐,830011
2. 新疆乌鲁木齐市友谊医院,新疆,乌鲁木齐,830000 |
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| 摘 要： | 目的:探讨DNA损伤修复基因BRCA1在晚期非小细胞肺癌(NSCLC)组织中的表达情况,对于含铂类化疗的治疗疗效影响以及预后意义。方法:应用二步免疫组织化学染色法对81例晚期非小细胞肺癌组织进行BRCA1基因定性检测,回顾调查入组患者的治疗方法、治疗反应,疗效评价、疾病进展时间及生存时间。组间差异采用卡方检验、疾病进展及生存期差异采用时序检验、Kaplan-Meier生存曲线进行统计分析。结果:81晚期非小细胞肺癌组织中BRCA1表达阳性率为51.9%,化疗有效率为43.2%;其中BRCA1阴性组化疗有效率为56.4%,BRCA1阳性组化疗有效率为31.0%,BRCA1阴性组化疗有效率高于阳性组,差异有统计学意义。BRCA1阴性组与阳性组中位疾病进展时间、中位生存期及1年生存率均无统计学差异。结论:晚期NSCLC中BRCA1的表达与临床特征无明显关联,BRCA1表达阴性有助于化疗成功,1年生存率较高,但总生存无差异。BRCA1可作为预测化疗疗效的指标之一。
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| 关 键 词： | 非小细胞肺癌 化疗 预后 BRCA1 |
Expression and prognostic significance of BRCA1 mRNA In advanced non small cell lung cancer |
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| SHAN Li,LIU Shen-hong,HAN Zhi-gang. Expression and prognostic significance of BRCA1 mRNA In advanced non small cell lung cancer[J]. Journal of Xinjiang Medical University, 2008, 31(12): 1724-1726 |
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| Authors: | SHAN Li LIU Shen-hong HAN Zhi-gang |
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| Affiliation: | Department of Medical Oncology;First Affiliated Tumor Hospital;Xingjiang Medical University;Urumqi 830011;China |
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| Abstract: | Objective:To investigate the expressions of BRCA1 members of DNA repair gene family in patients with advanced non small-cell lung cancer(NSCLC),the response to platinum-based chemotherapy as well as their clinical prognostic significance.Methods:Expression levels of BRCA1 were detected by method of immunohistochemistry in 81 advanced NSCLC patients.Retrospective studies on their treatment,therapeutic reactions,and progression time,survival time as well were done.Chi-square criterion,Kaplan-Meier survival cu... |
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| Keywords: | BRCA1 |
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