| 女贞子多糖对荷瘤小鼠免疫功能的影响 |
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| 作者姓名： | 李璘 邱蓉丽 周长慧 施樱樱 韩莹 陆茵 |
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| 作者单位： | 1. 南京中医药大学中医药研究院,江苏,南京,210029
2. 南京中医药大学药学院,江苏,南京,210046 |
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| 基金项目： | 江苏省高校自然科学基金，江苏省中医药管理局资助项目 |
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| 摘 要： | 目的研究女贞子多糖对荷瘤小鼠免疫功能的影响。方法用LPS及ConA分别刺激B淋巴细胞及T淋巴细胞,研究女贞子多糖对荷瘤小鼠B淋巴细胞及T淋巴细胞的影响;用Yac-1细胞作为靶细胞,研究其对荷瘤小鼠NK细胞的影响,同时也研究女贞子多糖对单核巨噬细胞吞噬功能的作用。结果女贞子多糖促进了荷瘤小鼠脾脏B淋巴细胞和T淋巴细胞的增殖,提高其NK细胞活性,同时,增强了荷瘤小鼠单核巨噬细胞的吞噬功能。结论女贞子多糖提高了荷瘤小鼠的免疫功能。
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| 关 键 词： | 女贞子多糖 荷瘤小鼠 免疫功能 |
Effect of Polysaccharides from Fructus Ligustri Lucidi on Immunity of Tumor-bearing Mice |
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| Authors: | LI Lin QIU Rong-li ZHOU Chang-hui SHI Ying-ying HAN Ying LU Yin |
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| Abstract: | OBJECTIVE To investigate into the effect of polysaccharides from Fructus Ligustri Lucidi on the immunity of tumor-bearing mice.METHOD LPS and ConA were used to stimulate B-and T-lymphocyte respectively to study the effect of the polysaccharides;Yac-1 cell was used as the target cell to study its effect on NK cell of tumor-bearing mice and the effect of polysaccharides from Fructus Ligustri Lucidi on the phagocytosis of macrophage.RESULT Polysaccharides from Fructus Ligustri Lucidi could promote the B-and T-lymphocyte proliferation and increase NK cell activity and the phagocytosis of macrophage.CONCLUSION Polysaccharides from Fructus Ligustri Lucidi increase the immunity of tumor-bearing mice. |
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| Keywords: | polysaccharides from Fructus Ligustri Lucidi tomor-bearing mice immunity |
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