可溶性细胞间黏附分子与急性期脑梗死体积的关系

目的 检测急性脑梗死(ACI)患者可溶性细胞间黏附分子(sICAM)的水平,评价其与急性期梗死体积的相关性.方法 采用双抗体夹心酶联免疫吸附法测定165例ACI患者血清sICAM～1水平,并与58例脑出血患者和87例健康体检者对照比较.结果 ACI组24h血清slCAM-1水平C(4.73+0.26)mg/L)]明显高于脑出血组((2.81士0.18)mg/L]和健康对照组[(2.64士0.25)mg/L],直至发病后14 d仍高于脑出血组和健康对照组(P均＜0.01).大梗死组(梗死灶＞10 cm3)血清sICAM-1水平[(5.14±0.34)mg/L]明显高于中梗死组[梗死灶4～10 cm3,(4.47±0.20)mg/L)和小梗死组[梗死灶＜4 cm3,(4.12士0.28)mg/L,P均＜0.01].ACI后伴感染组在14 d内血清slCAM-1水平均明显高于不伴感染组(P＜0.05或P＜0.01).结论 血清siCAM水平的变化与ACI梗死灶的大小密切相关.

A study of relation between changes in serum soluble intercellular adhesion molecule and infarction volume in patients with acute cerebral infarction

Objective To characterize relation between changes in serum soluble intercellular adhesion molecule (sICAM) and infarction volume in patients with acute cerebral infarction (ACI) .Methods The levels of serum sICAM-1 of 165 patients with ACI were measured with enzyme linked immunosorbent assay (ELISA),and compared the results with that of 58 patients suffering from cerebral hemorrhage and 87 normal controls.Results sICAM-1 in patients with ACI 24 hours after the onset (4.73±0.26) mg/L] was higher than that in patients with cerebral hemorrhage [(2.81± 0.18) mg/L] and normal controls [(2.64±0.25) mg/L,both P＜0.01].It was still higher than that in patients with cerebral hemorrhage and normal controls at the 14 clays after the onset (both P＜0.01).The levels of serum sICAM-1 were significantly higher in the patients with large cerebral infarction group [infaretion volume was ＞ 10 cm3,(5.14-4-0.34) rag/L] than in patients with medium[infarction volume was 4 - 10 cm3,(4.47+0.20) mg/L]and small cerebral infarction groups[infarction volume was ＜4 cm3,(4.12±0.28) mg/L,both P＜0.01].The levels of slCAM-1 were higher in patients complicated with infection compared with those without in 14 days (P＜0.05 or P＜ 0.01].Conclusion Serum sICAM-1 was closely related to cerebral infarction volume in patients with ACI.