| R-CHOP方案治疗老年弥漫大B细胞淋巴瘤患者疗效分析 |
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| 引用本文： | 朱志刚,李康保,许昕,张彩萍,孙启鑫,钟伟杰,朱国栋,孟凡义. R-CHOP方案治疗老年弥漫大B细胞淋巴瘤患者疗效分析[J]. 内科急危重症杂志, 2011, 17(6): 351-352 |
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| 作者姓名： | 朱志刚 李康保 许昕 张彩萍 孙启鑫 钟伟杰 朱国栋 孟凡义 |
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| 作者单位： | 1. 南方医科大学南方医院 广州 510180
2. 广州市第一人民医院 |
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| 摘 要： | 目的:评价R-CHOP方案治疗老年弥漫大B细胞淋巴瘤(DLBCL)患者的疗效及不良反应.方法:观察25例70～86岁DLBCL患者,用R-CHOP方案治疗8疗程,之后用美罗华单药维持(每3个月1次,维持2年)；分析化疗的疗效及不良反应.结果:19例达到完全缓解(CR),6例达到部分缓解(PR),无严重的不良反应.12例...
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| 关 键 词： | 老年 弥漫大B细胞淋巴瘤 联合化疗 |
Analysis of Therapeutic Effect of Rituximab in Combination With CHOP for Elderly Patients With Diffuse Large B-Cell Lymphoma |
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| ZHU Zhigang,LI Kangbao,XU Xin,et al.. Analysis of Therapeutic Effect of Rituximab in Combination With CHOP for Elderly Patients With Diffuse Large B-Cell Lymphoma[J]. Journal of Internal Intensive Medicine, 2011, 17(6): 351-352 |
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| Authors: | ZHU Zhigang LI Kangbao XU Xin et al. |
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| Affiliation: | ZHU Zhigang,LI Kangbao,XU Xin,et al. The NanFang hospital of Southern Medical University,Gnangzhou510180,China |
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| Abstract: | Objective： To evaluate the therapeutic effect and adverse reaction of rituximab in combination with CHOP （ R-CHOP） for the elderly patients with diffuse large B-cell lymphoma （ DLBCL） . Methods： Twenty-five elderly patients aged 75 ～ 80 with DLBCL were observed. Eight cycles of R-CHOP had been taken for every patients and maintenance therapy of single dose Mabthera had been used every 3 months and lasted for 2 years. The therapeutic effect and adverse reaction were analyzed. Results： Nineteen cases achieved complete remission （ CR） and 6 cases achieved partial remission （ PR） ,no serious adverse reaction had been observed. Twelve patients who had completed maintenance therapy of Mabthera for 2 years showed no recurrence in the follow-up. Conclusion： Combination of Mabthera with chemotherapy are well tolerated by elderly patients with DLBCL and without serious adverse reaction. |
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| Keywords: | The aged Diffuse large B-cell lymphoma Chemotherapy |
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