Physiological carbon dioxide, bicarbonate, and pH sensing |
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| Authors: | Martin Tresguerres Jochen Buck Lonny R. Levin |
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| Affiliation: | 1. Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, USA
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| Abstract: | In biological systems, carbon dioxide exists in equilibrium with bicarbonate and protons. The individual components of this equilibrium (i.e., CO2, HCO 3 ? , and H+), which must be sensed to be able to maintain cellular and organismal pH, also function as signals to modulate multiple physiological functions. Yet, the molecular sensors for CO2/HCO 3 ? /pH remained unknown until recently. Here, we review recent progress in delineating molecular and cellular mechanisms for sensing CO2, HCO 3 ? , and pH. |
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