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| 家族性肾透明细胞癌的遗传学研究现状 | |
| 引用本文： | 寿建忠,马建辉. 家族性肾透明细胞癌的遗传学研究现状[J]. 肿瘤研究与临床, 2006, 18(10): 649-651 |
| 作者姓名： | 寿建忠 马建辉 |
| 作者单位： | 100021,中国医学科学院中国协和医科大学肿瘤医院泌尿外科 |
| 摘 要： | 家族性肾透明细胞癌主要包括遗传性癌综合征伴发的肾透明细胞癌和单纯家族聚集性肾透明细胞癌两类，其中遗传性癌综合征伴发的肾透明细胞癌有希佩尔-林道病（VHL）、胚系3号染色体易位的家系、结节性硬化综合征和Birt-Hogg-Dube综合征中的伴发肾癌，文章就家族性肾透明细胞癌的遗传学研究现状进行了概述。 |
| 关 键 词： | 家族性肾透明细胞癌 遗传学 |
| 文章编号： | 1006-9801（2006）10-0649-03 |
| 收稿时间： | 2006-08-05 |
| 修稿时间： | 2006-08-05 |
Present status on the research of genetics of familial clear renal cell carcinoma |
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| SHOU Jian-zhong,MA Jian-hui. Present status on the research of genetics of familial clear renal cell carcinoma[J]. Cancer Research and Clinic, 2006, 18(10): 649-651 | |
| Authors: | SHOU Jian-zhong MA Jian-hui |
| Affiliation: | Department of Urinary Surgery, Cancer Hospital, Union Medical University, Chinese Academy of Medical Sciences, Beijing 100021, China |
| Abstract: | Familial clear renal cell carcinoma consists of hereditary clear renal cell carcinoma syndromes and familial non-syndromic renal cell carcinoma,of which the former can be the renal cell carcinoma accompanied with von Hippel-Lindau disease(VHL), Tuberous Sclerosis Complex(TSC), Birt-Hogg-Dube(BHD) syndrome and familial translocation of chromosomal 3. The most commonly involved gene includes VHL, TSC and BHD. Here, the current research status of familial clear renal cell carcinoma is reviewed. |
| Keywords: | Genetics Familial clear renal cell carcinoma |
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