TP与NP方案治疗晚期非小细胞肺癌的疗效比较

目的 :观察盐酸拓扑替康 +顺铂 (TP方案 )与重酒石酸长春瑞滨 (诺维本 ) +顺铂 (NP方案 )分别治疗晚期非小细胞肺癌(NSCLC)的临床疗效和不良反应。方法 :将50例NSCLC患者随机分为TP方案组 (21例 )和NP方案组 (29例 )。治疗周期均为21d ,2个治疗周期后评价疗效。结果 :TP、NP方案组有效率分别为52.4 %、51.7 % ,中位生存期分别为9.2mo、8 6mo ,均无显著性差异 (P>0.05)。NP方案组不良反应程度及发生率均高于TP方案组 ,但两组比较均无显著性差异 (P>0.05)。结论 :2种方案临床疗效相近 ,不良反应相似 ,耐受性均较好。

Comparison of the Efficacy between TP and NP Regimen Chemotherapy for Advanced Stage Non-small-cell Lung Cancer

OBJECTIVE:To compare the efficacy and toxicity of TP(topotecan hydrochloride cisplatin)and NP(navelbi_ ne cisplatin)regimen chemotherapy in treating non-small-cell lung cancer(NSCLC).METHODS:50patients with advanc_ ed stage NSCLC were randomly assigned to TP group(n=21)and NP group(n=29).The chemotherapy was repeated every21days as a cycle,and to evaluate efficacy after two cycles.RESULTS:The effective rate was52.4%for TP regimen group and51.7%for NP regimen group;the median survival time was9.2months for TP group and8.6months for NP group.There was no significant difference between the two groups(P>0.05).The degree and incidence of side effects in the NP group were higher than those in the TP group,but no significant difference was found between the two groups(P>0.05).CONCLUSIO_ NS:The two sets of regimen are similar in their efficacies and toxicity,both with satisfactory tolerance.