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In Vitro Activity of Tigecycline Against Orientia tsutsugamushi |
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| Authors: | Sun-Myoung Lee Hae-Yoon Kwon Jae-Hyoung Im Ji Hyeon Baek Seung-Sik Hwang Jae-Seung Kang Moon-Hyun Chung Jin-Soo Lee |
| Affiliation: | 1Translation Research Center, Inha University School of Medicine, Incheon, Korea.;2Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.;3Department of Social & Preventive Medicine, Inha University School of Medicine, Incheon, Korea.;4Department of Microbiology, Inha University School of Medicine, Incheon, Korea.;5Department of Internal Medicine, Hanmaeum Hospital, Jeju, Korea. |
| Abstract: | Scrub typhus is a zoonosis caused by Orientia tsutsugamushi (O. tsutsugamushi) occurring mainly in autumn in Korea. The need of new antibiotics has arisen with a report on strains resistant to antibiotics and chronic infection. This study aims to identify susceptibility of tigecycline in-vitro as a new therapeutic option for O. tsutsugamushi. Antibacterial activity of tigecycline against the O. tsutsugamushi was compared with doxycycline using flow cytometry assay. The inhibitory concentration 50 (IC50) was 3.59×10-3 µg/mL in doxycycline-treated group. Whereas in 0.71×10-3 µg/mL tigecycline-treated group. These findings indicate that tigecycline may be a therapeutic option for the treatment of scrub typhus. |
| Keywords: | Orientia tsutsugamushi scrub typhus tigecycline IC50 |