鼻咽癌患者血清新蝶呤、sCD4与sCD8检测的意义 |
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引用本文: | 王连聪,郑树,魏启春,束美宝,项建杰. 鼻咽癌患者血清新蝶呤、sCD4与sCD8检测的意义[J]. 浙江大学学报(医学版), 2001, 30(2): 70-72,89 |
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作者姓名: | 王连聪 郑树 魏启春 束美宝 项建杰 |
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作者单位: | 浙江大学医学院附属第二医院, |
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摘 要: | 目的探讨血清新蝶呤、sCD4及sCD8分子水平和鼻咽癌的关系及临床意义。方法采用ELISA方法检测54例初治鼻咽低分化鳞癌治疗前、后及32例健康成人的血清新蝶呤、sCD4与sCD8分子浓度。结果鼻咽癌血清新蝶呤、sCD4及sCD8浓度高于健康对照组(P<0.001)。不同TNM分期血清新蝶呤、sCD4及sCD8水平无差异(P>0.05);无淋巴结转移者血清新蝶呤低于有淋巴结转移者(P<0.05)。治疗后新蝶呤、sCD4与sCD8水平比治疗前明显降低(P<0.01),仍比对照组高(P<0.01);治疗后6月肿瘤全消者继续保持在较低水平,肿瘤残留者则回升到治疗前水平(P<0.01和0.05)。结论血清新蝶呤、sCD4与sCD8分子水平检测可作为鼻咽癌病情评估、疗效监测及随访的客观指标。
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关 键 词: | 鼻咽肿瘤 药物治疗 新蝶呤 SCD4 sCD8 抗原 |
文章编号: | 1008-9292(2001)0 2-0070-03 |
Measurement of SerumNeopterin and Soluble Lymphocyte Antigens(sCD4 and sCD8) in Patients with NasopharyngealCarcinoma and Its Clinical Significance |
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Abstract: | Objective:To evaluate the relationship betwe en serum levels of neopterin and sCD4 & sCD8 antigens and nasopharyngeal carcino ma and its clinical significance.Methods:The serum levels of neopter in and sCD4 & sCD8 antigens were determined in 54 patients with nasopharyngeal c arc inoma(NPC group) and 32 healthy adults(normal group) by ELISA.Results:The serum levels of neopterin and sCD4 & sCD8 antigens in NPC group were signi ficantly higher than those in normal group(P<0.001).The serum levels of neo pterin and sCD4 & sCD8 antigens were not related to UICC-TNM stages(P>0.05 ).The serum neopterin levels in patients without lymph node metastasis were lowe r than those with metastasis(P<0.05).The serum levels of neopterin and sCD4 & sCD8 antigens decreased significantly after raditoherapy(P<0.01).C onclusion:The measurement of the serum levels of neopterin and sCD4 & sCD8 antigens in patients with nasopha ryngeal carcinoma reflects disease status and may be a useful objective index to evaluate cellular immunological functions and curative effects and prognosis. |
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Keywords: | Nasopharyngeal neoplasms/drug ther Neopterin/ther use Antigens CD4/anal Antigens CD8/anal Prognosis |
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