| 钙营养对氟的骨骼毒性的影响 |
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| 引用本文： | 任立群 李广生. 钙营养对氟的骨骼毒性的影响[J]. 中国地方病防治杂志, 1999, 14(1): 3-5 |
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| 作者姓名： | 任立群 李广生 |
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| 作者单位： | 白求恩医科大学地方病研究所 |
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| 基金项目： | 国家自然科学基金资助项目,NO.39470633 |
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| 摘 要： | 用富钙平衡饲料和低钙偏食饲料分别饲养Ｗｉｓｔａｒ大鼠，并经饮水投予氟１００ｍｇ／Ｌ，为期４个月，以研究钙营养对氟的骨骼毒性的影响及其作用机理。
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| 关 键 词： | 钙营养 氟中毒 骨转换 骨骼毒性 |
EFFECT OF CALCIUM NUTRITION ON SKELETAL TOXICITY OF FLUORIDE |
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| Ren Liqun,et alInstitule of Endemic Diseases,Norman Bethune University of Medical Sciences. EFFECT OF CALCIUM NUTRITION ON SKELETAL TOXICITY OF FLUORIDE[J]. Chinese Journal of Control of Endemic Disenaces, 1999, 14(1): 3-5 |
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| Authors: | Ren Liqun et alInstitule of Endemic Diseases Norman Bethune University of Medical Sciences |
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| Abstract: | Effect of calcium nutrition on skeletal toxicity of fluoride and its mechanism were studied in Wis-tar rats fed on a balanced diet with adequate calcium or on a monotonous diet with low calcium and given fluoride in their drinking water (100mg/L F) for 4 months. Bone trabecula increased and thickened in metaphysis and the mumber of osteoclast increased in rats fed on an adequate calcium diet and fluoridized water. Osteomalacia, osteoporosis and accelerated bone turnover were observed with elevated serum alkaline phosphatase, osteocalcin, parathyroid hormone and decreased serum Ca and plasma Ca 2+ in rats fed on a low calcium diet and fluoridized water. Milder osteomalacia and osteoporosis with obvious biochemical changes could be induced by low calcium diet itself. These results indicate that adequate calcium nutrition can antagonize most skeletal toxicity caused by fluoride - poisoning and that low calcium and high fluoride possess the same effect on forming a high bone turnover state, which may be the pathogenetic basis for calcium malnutrition to exacerbate the severity of skeletal fluorosis. |
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| Keywords: | Calcium nutrition Fluoride-poisoning Bone turnover |
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