甘草对阿普唑仑在大鼠体内药动学特征的影响

目的研究甘草对阿普唑仑在大鼠体内药动学特征的影响。方法将14只SD大鼠随机分为对照组与实验组,分别予生理盐水和甘草提取物(0.5 g·kg^-1,qd×7d),灌胃给予阿普唑仑20 mg·kg^-1后按时间点连续采样,采用HPLC法测定血药浓度。采用DAS 2.0软件计算并比较主要药动学参数。结果对照组和实验组中阿普唑仑的主要药动学参数:ρ_max分别为（1 015.24±706.67）、（1170.81±682.69）μg·L（¹）,t_max分别为（0.52±0.18）、（0.52±0.18）h,t_1/2分别为（3.57±0.91）、（3.21±0.61）h,AUC_0→12h分别为（1 067.03±482.19）、（1 283.76±504.07）μg.h·L^-1,AUC_0→∞分别为（1 081.17±478.07）、（1 299.04±501.17）μg·h·L^-1MRT分别为（1.77±0.75）、（1.78±0.64）h。各参数在两组间比较,差异均无统计学意义（P>0.05）。结论甘草连续给药7 d后不影响阿普唑仑在大鼠体内的药动学特征。

Effect of licorice on alprazolam pharmacokinetics in rats

A/M To study the effect of licorice on alprazolam pharmacokinetics in mrs. METHODS Experimen- tal rats were randomly divided into control group and test group, that were administrated respectively with normal saline and extract of licorice. After pretreated with extract of licorice （0.5g·kg^-1, qd） for 7 d, alprazolam was given to the rats by intragastric administration at the dose of 20 mg·kg^-1. The plasma concentrations of alprazolam were determined by HPLC. Pharmacokinetic parameters between 2 groups were compared. RESULTS The main pharmacokinetic parameters of alprazolam for the control group and the test group were as follows： tmax were （ 1 015.24 ±706.67） and （1 170.81±682.69）ug.L-1, tmax were （0.52±0.18） and （0.52±0.18） h,tl/2 were （3.57±0.91） and （3.21 ±0.61） h, AUC0→12h were （1 067.03±482.19） and （1 283.76±504.07） ug.h.L-1, AUC0→12 were （1 081.17±478.07） and （ 1 299.04± 501.17）ug.h.L-1, MRT were （ 1.77±0.75） and （ 1.78±0.64） h, respectively. There were no significant differences in these pharmacokinetic parameters of alprazolam between 2 groups （ P 〉 0.05）. CONCLUSION The results suggest that treatment with extract of licorice （0.5 g.kg-1, qd） for7 d does not affect the phar-macokinetics of alprazolam in rats.