Survivin和uPA在结直肠腺瘤与腺癌中的表达及意义

目的：检测survivin蛋白在结肠腺瘤、腺癌中的表达,探讨其与增殖细胞核抗原（PCNA）、尿激酶型纤溶酶激活物（uPA）的关系。方法：应用免疫组织化学染色法检测survivin、uPA、PCNA蛋白在30例正常结直肠黏膜、30例结直肠非腺瘤性息肉、68例结直肠腺瘤、70例结直肠癌中的表达。结果：Survivin、UPA、PCNA的表达从结直肠正常黏膜、非腺瘤型息肉、腺瘤型息肉、腺癌逐渐增高,差异有统计学意义（P〈0.05）,并在此过程中survivin与PCNA呈正相关（P〈0.05）,survivin与PCNA表达呈正相关（P〈0.05）。结论：survivin和PCNA及UPA在结肠腺瘤中的发生、发展中起着协同的作用。

Expression and Clinical Significance of Surviving and uPA in Colorectal Carcinoma and Adenoma

Objective： To examine survivin proteins in colonic adenoma,adenocarcinoma with the expression,this paper explores its PCNA（PCNA）, the urokinase type fibrinolytic enzyme activate items（uPA） relationship.Metheds： Using immunohistochemical method to detect uPA,survivin,PCNA proteins in 30 cases of normal colorectal mucosa,30 patients with colorectal than adenomatous polyp,68 cases of colorectal adenomas,70 cases of colorectal cancer expression.Results： Survivin,expression of PCNA UPA,from colorectal adenoma normal mucosa,non type polyp,adenomatous polyp,adenocarcinoma type to rise,and each significant（P0.05）,and in the process Survivin PCNA positively correlated with（P 0.05）,Survivin positively correlated with PCNA expression（P 0.05）.Conclusion： PCNA and survivin and UPA in colonic adenoma of occurrence,development plays a synergistic effect.