|
|||||
|
|
Expression of voltage-dependent potassium channels in first trimester human placentae |
|
| Authors: | H.D. Mistry L.O. Kurlak G.S. Whitley J.E. Cartwright F. Broughton Pipkin R.M. Tribe |
| Affiliation: | 1. Division of Women''s Health, King''s College London, Women''s Health Academic Centre, KHP, St Thomas'' Hospital, Westminster Bridge Road, London SE1 7EH, UK;2. Department of Nephrology, Hypertension, Clinical Pharmacology and of Clinical Research, University of Bern, Berne CH-3010, Switzerland;3. Department of Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham NG5 1PB, UK;4. Division of Biomedical Sciences, St George''s University of London, London SW17 0RE, UK |
| Abstract: | Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (KV7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at ≤10 weeks' (early TOP) and >10 weeks' (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P = 0.022). This novel study reports mRNA and protein expression of KV7 channels in first trimester placentae. |
| Keywords: | Potassium channel Placenta Early pregnancy KCNQ KCNE |
| 本文献已被 ScienceDirect 等数据库收录！ | |