Relationship between augmentation index and acute ischemic stroke subtype |
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| Affiliation: | 1. Department of Neurological Surgery, Northwestern University McGaw Medical Center, 676 N. St. Clair Street, Suite 2210, Chicago, IL 60611, USA;2. Department of Pathology, Northwestern University McGaw Medical Center, Chicago, IL, USA;3. Department of Radiation Oncology, Northwestern University McGaw Medical Center, Chicago, IL, USA;1. University of Virginia, Department of Neurological Surgery, P.O. Box 800212, Charlottesville, VA 22908, USA;2. University of Virginia, Department of Radiology, Charlottesville, VA, USA;1. Cerebrovascular Center, Cleveland Clinic, Cleveland, OH, USA;2. Departments of Neurosurgery and Radiology, University of Texas Southwestern, Dallas, TX, USA;1. Department of Neurosurgery, University of Michigan, 1500 E. Medical Center Drive, Room 3552 TC, Ann Arbor, MI 48109-5338, USA;2. Department of Orthopedics, University of Michigan, Ann Arbor, MI, USA;1. Division of Neurovascular Surgery and Endovascular Neurosurgery, Department of Neurosurgery, Thomas Jefferson University Hospital, 909 Walnut Street, Philadelphia, PA 19107, USA;2. Rancocas Valley Anesthesia, Cinnaminson, NJ, USA;1. Department of Anatomic Pathology, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA;2. Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA |
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| Abstract: | ![]()
The aim of the present study was to explore the relationship between augmentation index (AIx) and vascular risk factors according to stroke subtypes. Patients were eligible for this study if they experienced their first ischemic stroke within the preceding 7 days and were 45 years of age or older. AIx was measured by applanation tonometry (SphygmoCor, AtCor Medical, Sydney, Australia) and ischemic stroke was classified according to the Trial of Org 10172 in the Acute Stroke Treatment (TOAST) classification system. A total of 189 patients were enrolled. The most frequent stroke subtype was lacune (76, 40.2%), followed by stroke of undetermined etiology, negative work-up (SUDn) (59, 31.2%), large artery atherosclerosis (LAA) (31, 16.4%), and cardioembolism (23, 12.2%). While there were no significant differences among the groups for hemodynamic indices, AIx at 75 beats per minute (AIx@75) was higher in lacune subtype (29.6%) than SUDn (28.4%), LAA (26.6%), and cardioembolism (24.8%) (p = 0.064). The AIx@75 was significantly related to age (r = 0.189), sex (r = 0.252), peripheral systolic blood pressure (SBP) (r = 0.189), peripheral diastolic blood pressure (DBP) (r = 0.191), and peripheral mean arterial pressure (MAP) (r = 0.327). Multiple linear regression analysis revealed that age, sex, peripheral SBP, peripheral DBP and peripheral MAP were significant (p < 0.002). This study showed that arterial stiffness is increased in acute lacunar infarction. Considering the pathogenesis of lacunar infarction and the potential interconnected causes of arterial stiffness, our findings indicate that increased arterial stiffness in acute lacunar infarction may be related to the pathogenesis of lacunar infarction. |
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| Keywords: | Arterial stiffness Augmentation index Ischemic stroke |
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