肺动脉高压与脑利钠肽、血管内皮功能和炎性细胞因子的相关性

摘 要：目的 通过观察肺动脉高压（PAH）患者的肺动脉收缩压（PASP）与脑利钠肽（BNP）、血管内皮功能和炎性细胞因子的相关性，进一步探讨PAH发病机制。方法 测定92例PAH患者和50例健康者的肺动脉收缩压（PASP）、血浆BNP、内皮素-1（ET-1）、血清一氧化氮（NO）、超敏C反应蛋白（hs-CRP）和肿瘤坏死因子-α（TNF-α）等指标。结果 PAH患者的血浆BNP、ET-1、血清hs-CRP和TNF-α显著高于对照组（P<0.05），血清NO显著低于对照组（P<0.05）。PAH患者的PASP与血浆BNP（r=0.574）、hs-CRP（r=0.423）、ET-1（r=0.402）和TNF-α（r=0.366）呈显著正相关；与血清NO水平呈显著负相关（r=-0.378）。结论 PAH的发生发展过程是BNP、内皮系统和炎性反应等多因素综合作用的结果。

The correlation between PASP and brain natriuretic peptide,endothelial function,inflammatory mediators in pulmonary artery hypertension

Abstract Objective: To investigate the correlation between PASP and brain natriuretic peptide (BNP), endothelial function, inflammatory mediators and evaluate mechanism of pulmonary artery hypertension (PAH). Methods: Pulmonary artery systolic pressure (PASP), plasma BNP, endothelin-1 (ET-1), serum nitric oxide (NO), serum hyper sensitive C-reactive protein (Hs-CRP), tumor necrosis factor-α (TNF-α) were measured in 92 patients with PAH and 50 healthy persons. Results: Compared with healthy persons, BNP, ET-1, hs-CRP and TNF-αwere significantly increased (P<0.05), while serum NO were reduced in patients with PAH (P<0.05). PASP in patients with PAH were positively correlated with plasma BNP(r=0.574), hs-CRP(r=0.423), ET-1(r=0.402) and TNF-α(r=0.366); while negatively correlated with serum NO(r=-0.378). Conclusion: The occurance of PAH is decided by interrelation of natriuretic peptide system, endothelial system and inflammation.