血栓性血小板减少性紫癜临床分析

目的：探讨血栓性血小板减少性紫癜（TTP）的病因、临床特点和治疗效果，以加深对该病的认识。方法：对15例TTP的类型、临床表现、治疗及预后进行回顾性分析。结果：15例中女性9例。原发性TTP10例，继发性TTP5例；5例继发性TTP中，感染所致2例，自身免疫性疾病1例，药物1例，妊娠1例。15例患者均为急性起病。临床主要表现为血小板减少、微血管病性溶血性贫血、神经精神障碍、发热及肾脏损害。5例继发性TTP患者以血浆置换（PE）和病因治疗为主，均治愈。10例原发性TTP采用以血浆置换为主的综合治疗，6例治愈，1例复发，3例死亡。结论：TTP的治疗应强调PE和输注新鲜冰冻血浆的重要性。

Clinical Analysis of Thrombotic Thrombocytopenic Purpura

Objective:To investigate the pathogenisis,clinical characteristic and therapeutic response of thrombotic thrombocytopenic purpura (TTP). Methods: Clinical manifestations,treatment and prognosis of 15 cases with TTP were analyzed retrospectively. Results: Nine of 15 cases were female. 10 cases were idiopathic TTP and 5 were secondary. The secondary TTP were caused by infection (2 cases),autoimmune disease (1 case),drug (1 case) and pregnancy (1 case). All the patients with TTP developed and progressed rapidl...