Toll样受体与EB病毒感染研究进展

Toll样受体(TLRs)是一类能识别微生物,特别是细菌和病毒的模式识别受体,可对病原体相关分子模式进行识别、结合,并引发一系列信号转导,进而导致炎性介质的释放,在天然免疫防御中起着重要作用,并最终激活获得性免疫系统。研究发现,在EB病毒感染时TLRs可以促进B淋巴细胞增殖和活化,从而起到保护宿主的作用。因此,研究并阐明EB病毒激活和抑制TLRs的胞内信号转导途径及机制,对EB病毒相关性疾病的防治具有重要意义。

The Advance about Toll-like Receptors in Epstein-Barr Virus Infectious

The toll receptors are one example of pattern-recognition receptors whose importance has been shown by their evolutionary conservation between invertebrates and vertebrates. The mammalian toll-like receptors（TLRs） , originally described for their homology with the Drosophila toll, are a family of transmem- brahe receptors containing extracellular leucine-rich regions, which recognize various microbial components engaging a signaling cascade that results in the response versus such microbes. EBV induces infectious mononucleosis causing B cell activation and autoantibody production, The latent membrane protein is EBV-encoded protein, which can increases the reactivity and sensitivity of B cells to TLR activation. Recently, Toll-like receptor（TLR） signaling has been reported to provide a third B-cell activation stimulus. The interaction between the EBV and TLR pathways was therefore investigated, which may become a new prophylaxis and therapeutic approach of Epstein-Barr virus associated disease.