早中期食管鳞状细胞癌中Notch1与血管内皮生长因子C的表达及其意义

Objective To study the expression of Notch1 and vascular endothelial growth factor C (VEGF-C) in early metaphase esophageal squamous cell carcinoma (ESCC) and its relationship with the clinicopathological characters. Methods Tissue slices of 40 ESCC and 8 normal esophagus tissues were collected during esophagectomy in our hospital from May 2007 to December 2007. The expression of Notch1 and VEGF-C was detected by immunohistochemistry. The correlation between Notch1 and VEGF-C and the relationship with the clinicopathological characters were discussed. Results Compared in early metaphase ESCC to that in normal tissue, Notch1 was obviously low expressed [47.5%(19/40) vs 100.0%(8/8) ,P=0.006) ], and VEGF-C was high expressed[ 67.5%(27/40) vs 0.0%(0/8) ,P=0.000]. Notch1 expression rate in different phase ESCC was 80.0%(8/10, well-differentiated), 50.0%(7/14, moderate-differentiated), 25.0%(4/16, poor-differentiatedwhile),respectively. The positive expression rate of Noch1 decreased with the decrease of differentiation degree (P=0.023), but there was no significant differences between infiltration degree and lymph node metastasis(P＞0.05).While VEGF-C expression rate was 30.0%(3/10, well-differentiated), 71.4%( 10/14, moderate-differentiated),81.3% (13/16, poor-differentiated), respectively. The expression of VEGF-C increased with the decrease of differentiation degree(P=0.024). VEGF-C expression in lymph nodes metastasis group was higher than that in no lymph nodes metastasis group [ 100.0 % (16/16) vs 45.8 % ( 11/24 ), P=0.000 ]. Compared with T2 group, the positive rate of VEGF-C expression was higher in T3-T4 group in ESCC tissue [ 82.1%(23/28) vs 33.3% (4/12),P=0.000 ]. Correlation was negative between Notch 1 and VEGF-C (r=-0.486, P=0.003). Conclusions Notch 1may be one of the anti-oncogenes in early metaphase ESCC. The aberrant low expression of Noch1 may lead to aberrant high expression of VEGF-C.

Expression of Notch1 and vascular endothelial growth factor C and its significance in early metaphase esophageal squamous cell carcinoma