| 广州市新型冠状病毒肺炎病例密切接触者核酸检测灵敏度和特异度分析 |
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| 引用本文： | 张文婷,刘丹,谢朝军,申动,陈宗遒,李志浩,刘远,张希如,陈沛良,钟文芳,杨佩,黄清湄,罗雷,毛琛. 广州市新型冠状病毒肺炎病例密切接触者核酸检测灵敏度和特异度分析[J]. 中华流行病学杂志, 2021, 42(8): 1347-1352 |
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| 作者姓名： | 张文婷 刘丹 谢朝军 申动 陈宗遒 李志浩 刘远 张希如 陈沛良 钟文芳 杨佩 黄清湄 罗雷 毛琛 |
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| 作者单位： | 南方医科大学公共卫生学院流行病学系, 广州 510515;广州市疾病预防控制中心 511430 |
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| 基金项目： | 广东省高等学校珠江学者岗位计划（2019）；广东省高水平大学建设计划（G820332010，G618339167，G618339164）；中国科协青年人才举托工程（2019QNRC001）；国家自然科学基金（82041030）；浙江大学COVID-19应急科研专项（K920330111） |
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| 摘 要： | 目的:分析广州市新型冠状病毒肺炎（COVID-19）疫情防控不同阶段中，密切接触者新型冠状病毒（新冠病毒）核酸检测的灵敏度和特异度，为优化疫情防控策略提供科学依据。方法:2020年2月21日至9月22日广州市COVID-19病例的密切接触者20 348例，均已接受新冠病毒核酸检测。针对疫情防控的不同阶段，比较核酸检测的...
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| 关 键 词： | 新型冠状病毒肺炎 核酸检测 诊断 灵敏度 特异度 |
| 收稿时间： | 2020-12-11 |
Sensitivity and specificity of nucleic acid testing in close contacts of COVID-19 cases in Guangzhou |
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| Zhang Wenting,Liu Dan,Xie Chaojun,Shen Dong,Chen Zongqiu,Li Zhihao,Liu Yuan,Zhang Xiru,Chen Peiliang,Zhong Wenfang,Yang Pei,Huang Qingmei,Luo Lei,Mao Chen. Sensitivity and specificity of nucleic acid testing in close contacts of COVID-19 cases in Guangzhou[J]. Chinese Journal of Epidemiology, 2021, 42(8): 1347-1352 |
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| Authors: | Zhang Wenting Liu Dan Xie Chaojun Shen Dong Chen Zongqiu Li Zhihao Liu Yuan Zhang Xiru Chen Peiliang Zhong Wenfang Yang Pei Huang Qingmei Luo Lei Mao Chen |
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| Affiliation: | Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China;Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 511430, China |
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| Abstract: | Objective To analyze the sensitivity and specificity of SARS-CoV-2 nucleic acid testing in 20 348 close contacts of COVID-19 cases in different prevention and control stages in Guangzhou and to provide scientific evidence for optimizing epidemic response strategies.Methods A total of 20 348 close contacts of COVID-19 cases in Guangzhou were traced between February 21 and September 22,2020. All the close contacts were tested for the nucleic acid of SARS-CoV-2. The sensitivity and specificity of nucleic acid testing and diagnosis in the different prevention and control stages were compared. Results In 20 348 close contacts, 12 462 were males (61.24%), the median (P25,P75) of age of them was 31.0 years (23.0,43.0), the median number (P25,P75) of nucleic acid testing for them was 2.0 (1.0,3.0), and the median (P25,P75) of their quarantine days was 12.0 (8.0,13.0) days, respectively. A total of 256 COVID-19 cases were confirmed in the close contacts after seven nucleic acid tests. In the 1st, 2nd, 3rd and 7th nucleic acid testing, the sensitivity and specificity were 69.14% and 99.99% (177 cases confirmed), 89.84% and 99.99% (230 cases confirmed), 97.27% and 99.99% (249 cases confirmed), and 100.00% and 99.98%, respectively. In the three stages of COVID-19 prevention and control in China:domestic case stage, imported case stage, and imported case associated local epidemic stage, the sensitivity of the 1st nucleic acid testing was 70.68%, 68.00% and 67.35%, and the specificity was 99.98%, 100.00% and 100.00%, respectively. Conclusions The sensitivity of nucleic acid testing in the close contacts at the different stages were consistent with slight decrease, which might be related to the increased proportion of asymptomatic infections in the late stage of epidemic prevention and control with COVID-19 in Guangzhou. It is suggested to give three nucleic acid tests to improve the sensitivity and reduce false negative risk. |
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| Keywords: | COVID-19 Nucleic acid testing Diagnosis Sensitivity Specificity |
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