Regulatory T cells: immune suppression and beyond |
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| Authors: | Yisong Y Wan |
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| Affiliation: | Lineberger Comprehensive Cancer Center, Department ofMicrobiology and Immunology, The University of North Carolina at ChapelHill, School of Medicine, North Carolina, NC, USA |
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| Abstract: | Foxp3-expressing regulatory T cells (Tregs) were originally identified ascritical in maintaining self-tolerance and immune homeostasis. Theimmunosuppressive functions of Tregs are widely acknowledged and have beenextensively studied. Recent studies have revealed many diverse roles of Tregs inshaping the immune system and the inflammatory response. This review willdiscuss our efforts as well as the efforts of others towards understanding themultifaceted function of Tregs in immune regulation. |
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| Keywords: | Foxp3 Treg immunosuppression and plasticity |
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