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| 孕早期脂蛋白a水平与妊娠期糖尿病的前瞻性队列研究 | |
| 引用本文： | 陈逍天,叶莹,张羿,姜袁,王胤,陈红燕,窦亚兰,李梦茹,孙绪鹏,严卫丽. 孕早期脂蛋白a水平与妊娠期糖尿病的前瞻性队列研究[J]. 中华流行病学杂志, 2021, 42(5): 903-908 |
| 作者姓名： | 陈逍天 叶莹 张羿 姜袁 王胤 陈红燕 窦亚兰 李梦茹 孙绪鹏 严卫丽 |
| 作者单位： | 复旦大学附属儿科医院临床流行病学研究室, 上海 201102;复旦大学附属儿科医院皮肤科, 上海 201102;复旦大学附属儿科医院临床试验中心, 上海 201102;复旦大学附属儿科医院临床流行病学研究室, 上海 201102;复旦大学附属儿科医院临床试验中心, 上海 201102 |
| 基金项目： | 国家重点研发计划（2016YFC1000506）；中国医学科学院小儿遗传相关性心血管疾病早期防控创新单元（2018RU002）；中国医学科学院医学与健康科技创新工程项目（2019-IZM-5-002） |
| 摘 要： | 目的:探讨孕早期脂蛋白a（Lpa）水平与妊娠期糖尿病（GDM）的关系。方法:以“母体关键营养素与子代特应性皮炎”队列中的445名孕12~14周孕妇为研究对象，通过问卷调查收集一般人口学特征，检测孕早期空腹糖脂代谢指标，随访孕24~28周口服糖耐量试验（OGTT）结果。应用多因素logistic回归分析Lpa水平与GDM... |
| 关 键 词： | 妊娠期糖尿病 脂蛋白a 孕早期 队列研究 |
| 收稿时间： | 2020-08-04 |
Association of lipoprotein a in early pregnancy with gestational diabetes mellitus: a prospective cohort study |
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| Chen Xiaotian,Ye Ying,Zhang Yi,Jiang Yuan,Wang Yin,Chen Hongyan,Dou Yalan,Li Mengru,Sun Xupeng,Yan Weili. Association of lipoprotein a in early pregnancy with gestational diabetes mellitus: a prospective cohort study[J]. Chinese Journal of Epidemiology, 2021, 42(5): 903-908 | |
| Authors: | Chen Xiaotian Ye Ying Zhang Yi Jiang Yuan Wang Yin Chen Hongyan Dou Yalan Li Mengru Sun Xupeng Yan Weili |
| Affiliation: | Department of Clinical Epidemiology, Children''s Hospital of Fudan University, Shanghai 201102, China;Department of Dermatology, Children''s Hospital of Fudan University, Shanghai 201102, China;Department of Clinical Trial Unit, Children''s Hospital of Fudan University, Shanghai 201102, China; Department of Clinical Epidemiology, Children''s Hospital of Fudan University, Shanghai 201102, China;Department of Clinical Trial Unit, Children''s Hospital of Fudan University, Shanghai 201102, China |
| Abstract: | Objective To investigate the association of lipoprotein a (Lpa) in early pregnancy with gestational diabetes mellitus (GDM) risk. Methods A total of 445 pregnant women in 12-14 gestational weeks from "Maternal Key Nutritional Factors and Offspring''s Atopic Dermatitis" cohort were included in this study. The demographic characteristics of participants were collected by using questionnaires, and the fasting glucose and lipids levels in early pregnancy were measured. The results of oral glucose tolerance test (OGTT) between 24-28 gestational weeks were recorded. Multivariate logistic regression model was applied to analyze the association of Lpa with GDM by calculating the OR and 95%CI after adjustment for covariates. Results The incidence number of GDM was 78 (17.5%). The Lpa level in pregnant women with GDM was significantly higher than that in pregnant women without GDM[105.5 (92.0, 122.0) vs. 97.0 (87.0, 109.0) mg/L], P<0.05. Lpa was significantly associated with GDM risk[OR (95%CI)=1.21(1.08-1.36) per 10 mg/L], P<0.05. The association was still significant after adjustment for covariates including age, gestational weeks et al, the adjusted OR was 1.14 (95%CI:1.01-1.30), P=0.03. Conclusions The elevation of Lpa in early pregnancy is one of risk factor for GDM. Maintaining normal Lpa level during early pregnancy can benefit early prevention of GDM and offspring health. |
| Keywords: | Gestational diabetes mellitus Lipoprotein a Early pregnancy Cohort study |
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