| 克林霉素致不良反应215例临床分析 |
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| 引用本文： | 曾佳,黎行山,李艳,杨爱群,李江华,谭杭. 克林霉素致不良反应215例临床分析[J]. 广东药学院学报, 2006, 22(1): 80-81 |
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| 作者姓名： | 曾佳 黎行山 李艳 杨爱群 李江华 谭杭 |
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| 作者单位： | 广东药学院附属第一医院,药剂科,广东,广州,510080;广州港港湾医院,药剂科,广东,广州,510700;广东药学院 |
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| 摘 要： | 目的探讨克林霉素致药物不良反应(ADR)的一般规律及特点,为临床合理用药提供参考.方法对近11年国内医药期刊报道的克林霉素所致不良反应215例进行分类统计、分析.结果 215例ADR病例涉及15个器官/系统类型,前3位是皮肤及其附件损害、胃肠系统损害及中枢和外周神经系统损害.结论临床应重视克林霉素的合理使用,警惕可能因药物的相互作用诱发严重ADR的潜在危害性.
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| 关 键 词： | 克林霉素 器官及系统损害 药物不良反应 合理用药 |
| 文章编号： | 1006-8783(2006)01-0080-02 |
| 收稿时间： | 2005-10-09 |
| 修稿时间： | 2005-11-23 |
Analysis of 215 cases adverse reaction caused by clindamycin |
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| ZENG Jia,LI Hang-Shan,LI Yan,YANG Ai-qun,LI Jiang-hua,TAN Hang. Analysis of 215 cases adverse reaction caused by clindamycin[J]. Academic Journal of Guangdong College of Pharmacy, 2006, 22(1): 80-81 |
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| Authors: | ZENG Jia LI Hang-Shan LI Yan YANG Ai-qun LI Jiang-hua TAN Hang |
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| Affiliation: | 1. The First Affiliated Hospital of Guangdong College of Pharmacy, Guangzhou 510080, China ; 2. The Hospital of Guangzhou harbor, Guangzhou 510700 China ; 3. The Trainee of Guangdong College of Pharmacy, Guangzhou 510006, China |
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| Abstract: | Objective To discuss the general regularity and the characteristics of the adverse reaction resulting from clindamycin to provide references for the clinic. Methods 215 cases of adverse reaction resulting from clindamycin covered by the medical and pharmaceutical periodicals in the recent 11 years were classified and analyzed statistically. Results 15 organs/systems were involved and the commonest ADRs were damages of skin and its appendages, digestive system, central and peripheral nervous system, Conclusion Clindamycin should be used with caution in patients with a history of hypersensitivity due to the potential danger of significant diarrhea, hematuria and respiratory depression mainly because of drug interactions. |
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| Keywords: | clindamycin damages of organs/systems adverse drug reactions drug safety |
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