vWF、PAI-1与糖尿病肾病关系的研究进展

糖尿病发生时,体内凝血及纤溶功能会发生一系列变化。血管性假性血友病因子(vWF)作为凝血功能的指标,是血管内皮细胞损伤的标志物。纤溶酶原激活物抑制剂1(PAI-1)的水平能反映纤溶活性。糖尿病并发微血管病变尤其是糖尿病肾病时,两者的水平显著升高。vWF、PAI-1与糖尿病肾病关系的研究对于认识糖尿病肾病的发生机制及对糖尿病肾病的诊断和治疗有重要的临床意义。

Study on the Relationship of Diabetic Nephropathy with Von Willebrand Factor and Plasminogen Activator Inhibitor-1

Patients with diabetes will experience a series of changes ofthe body blood coagulation and fibrinolytic function.As the index of blood coagulation function,vWF is an important maker of endothelial injury.And the level of PAI-1 in plasma can represent the fibrinolytic activity.The levels of both indexes mentioned increase significantly when diabetic patients suffer from microvascular complications especially diabetic nephropathy.The study on the relationship of diabetic nephropathy with vWF and PAI-1 has important clinical significance to understand the pathogenesis of diabetic nephropathy,and to the early diagnosis and treatment.