| Th1/Th2/Th17/Treg细胞因子在变应性鼻炎发病中的免疫机制研究 |
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| 引用本文： | 张仲林,;钟玲,;袁明勇,;唐春梅,;凌保东.Th1/Th2/Th17/Treg细胞因子在变应性鼻炎发病中的免疫机制研究[J].医学综述,2014(16):2906-2909. |
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| 作者姓名： | 张仲林 ;钟玲 ;袁明勇 ;唐春梅 ;凌保东 |
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| 作者单位： | [1]四川省高校结构特异性小分子药物重点实验室,成都610083; [2]成都医学院药学院,成都610083 |
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| 基金项目： | 四川省科技厅项目（2012JY0035）; 四川省中医管理局项目（2008-04） |
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| 摘 要： | 变应性鼻炎(AR)是免疫球蛋白E(IgE)介导的鼻黏膜的Ⅰ型变态反应性疾病,既往认为AR是由Th1/Th2型细胞因子的不平衡引发的。然而,目前研究发现还有其他多种免疫细胞和细胞因子参与了AR的发生、发展,因而Th1/Th2的细胞模式现已经扩展为Th1/Th2/Th17/Treg细胞模式。该文复习既往研究文献,锁定与AR密切相关的Th1/Th2/Th17/Treg细胞因子系统,对该系统在AR发生、发展的免疫学机制进行综述。扩展后的Th1/Th2/Th17/Treg细胞模式更有助于对疾病的理解,将推动AR的发病原因探讨、药物的干扰机制阐释以及相关靶点新药开发等研究工作,为基础理论研究和临床治疗提供可借鉴的思路。
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| 关 键 词： | 变应性鼻炎 Th1/Th2/Th17/Treg细胞 细胞因子 免疫机制 |
Study on Th1/Th2/Th17/Treg in the Immune Mechanism of Allergic Rhinitis Onset |
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| Institution: | ZHANG Zhong- lin, ZHONG Ling, YUAN Ming-yong, TANG Chun-mei, LING Bao-dong ( 1. Key Laboratory of Small Molecule Special Structure Drugs, Sichuan Institutions of Higher Education, Chengdu 610083, China; 2. School of Pharmacy, Chengdu Medical College, Chengdu 610083, China) |
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| Abstract: | Allergic rhinitis（AR） is a disease of type I allergy of nasal mucosa mediated by IgE,previously thought to be caused by Th1/Th2 cytokine imbalance. However, the current studies have found that various other immune cells and cytokines are involved in AR,so the Th1/Th2 cell model has been extended to Th1/ Th2/Th17/Treg cell model. Upon reviewing the lectures, here is to summarize the immune mechanisms of AR focusing on the Th1/Th2/Th17/Treg cytokine system closely related to AR. The cells model of Th1/Th2/ Th17/Treg will improve the understanding of AR, promote the investigation of aetiologieal agent, improve the explaination of the action mechanism of the related drugs and develop new drugs on the targets, which can offer referential thoughts to the basic and clinical research of AR. |
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| Keywords: | Rhinitis allergic Th1/Th2/Th17/Treg cell Cytokines Immunologic mechanism |
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