| 成人乙型肝炎病毒感染后慢性化机制及研究进展 |
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| 引用本文： | 王宇,刘沛. 成人乙型肝炎病毒感染后慢性化机制及研究进展[J]. 医学综述, 2014, 0(12): 2141-2143 |
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| 作者姓名： | 王宇 刘沛 |
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| 作者单位： | 中国医科大学附属第一医院传染科,沈阳110001 |
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| 摘 要： | 导致急性乙型肝炎病毒(HBV)感染后慢性化的因素包括病毒因素和宿主因素,HBV不能从人体内被清除,就形成慢性化。病毒因素主要是HBV通过多种途径达到的免疫逃逸作用及病毒引起的免疫抑制作用等使宿主不能清除病毒;宿主因素主要是免疫耐受或免疫功能低下,使宿主不能产生有效的抗病毒免疫应答,而使HBV持续存在于肝细胞内并可保持活动性复制状态。
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| 关 键 词： | 乙型肝炎病毒 病毒因素 宿主因素 免疫逃逸 免疫耐受 |
The Mechanisms of Chronicity in Hepatitis B Virus Infection in Adults |
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| Affiliation: | WANG YU,shenyang (Department of Infectious Diseases, the First Hospital Affiliated to China Medical University, 110001 ,China) |
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| Abstract: | The risks of chronicity following acute HBV infection include viral and host factors. If HBV cannot be cleared from the body,due to immune escape or immunosuppression of the virus,or immune tolerance or immunocompromise of the host which result in ineffective antiviral immune response, then HBV may continue to exist in the hepatic cells and keep at an active and replicating state. |
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| Keywords: | Hepatitis B virus Virus factors Host factors Immune escape Immune tolerance |
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