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| 胸苷激酶基因治疗人脑胶质瘤SHG44的研究 | |
| 引用本文： | 潘玉君 惠国桢. 胸苷激酶基因治疗人脑胶质瘤SHG44的研究[J]. 中华神经外科杂志, 1996, 12(5): 299-302 |
| 作者姓名： | 潘玉君 惠国桢 |
| 作者单位： | 苏州医学院附一院脑外科，上海复旦大学遗传所 |
| 摘 要： | 构建了含有ｐｇｋ启动子驱动的ＨＳＶ－ｔｋ基因的反转录病毒载体ｐＬＮＴＫ，并成功地转移至人脑胶质瘤ＳＨＧ４４细胞。体内实验证实，ＡＣＶ可抑制ＳＨＧＬＮＴＫ的肿瘤形成，并可抑制ＳＨＧＬＮＴＫ肿瘤的生长。原位基因转移治疗ＳＨＧ４４肿瘤效果明显。提示其可作为脑肿瘤治疗的一种新方法。 |
| 关 键 词： | 胸苷激酶基因 基因治疗 脑胶质瘤 Acyclovir（ACV） |
TheinvivostudyonhumangliomaSHG44treatedwiththymidinekinasegene |
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| PanYujun,HuiGuozhen,HuJin,et al.. TheinvivostudyonhumangliomaSHG44treatedwiththymidinekinasegene[J]. Chinese Journal of Neurosurgery, 1996, 12(5): 299-302 | |
| Authors: | PanYujun HuiGuozhen HuJin et al. |
| Affiliation: | PanYujun,HuiGuozhen,HuJin,etal.DepartmentofNeurosurgery.TheFirstAfiliatedHospitalofSuzhouMedi-calColege,Suzhou215006 |
| Abstract: | RetroviralvectorpLNTKcaringHSV-tkgenedrivenbypgkpromoterwereconstructedandsucessfulytransferedintohumangliomacelSHG44.TheinvivostudyconfirmedthatACVcouldsuppresthetumorformationoftheSHGLNTKcelsandthegrowthofSHGLNTKtumors.ThisdemonstratedthatSHGLNTKtumorcelsweretreatedinsituwithinjectionretrovirussupernatantwithcontainedHSV-tkandimplantationofPA317celswhichproducedretroviralvectorpLNTK.There-sultsshowedthatsuchgenetransfertreatmentweremoreefectiveandindicatedthatsuchtreatmentmaybeusedasaninnovativemethodforbraintumortherapy. |
| Keywords: | GenesGliomaAcylovir |
| 本文献已被 CNKI 维普 等数据库收录！ | |