小儿肾积水尿EGF和MCP-1水平的检测及意义分析

目的探讨小儿肾积水患者的尿表皮生长因子（EGF）与单核细胞趋化蛋白（MCP-1）的检测结果,分析两者对患者的临床意义。方法对2001年1月至2011年8月收治的58例小儿肾积水患者和同期健康体检的小儿进行EGF和MCP-1检查,比较两组的检查结果是否存在差异。结果肾积水患儿与正常对照组比较,EGF和MCP-1均明显升高,差异有统计学意义（P〈0．05）。结论对小儿肾积水患者采用尿EGF、MCP-1水平的检测具有较高的临床价值,可辅助对患者肾脏水平进行判断。

Study on significance of detection of urine levels of EGF and MCP-1 in pediatric patients with hydronephrosis

Objective To explore the clinical significance of detection of urine levels of epidermal growth factor （EGF） and monocyte chemoattractant protein 1 （ MCP - 1 ） in pediatric patients with hydronephrosis and to analyze their clinical significance. Methods Fifty eight pe- diatric patients with hydronephrosis were treated in this hospital during January 2001 to August 2011, and their urine levels of EGF and MCP - 1 were examined and compared. Results Urine level of EGF in pediatric patients with hydronephrosis was significantly higher than that of control group （ P 〈 0.05 ） ; urine level of MCP - 1 in patients with hydronephrosis was also significantly higher than that of control group （ P 〈 0.05 ）. Conclusion The detection of urine levels of EGF and MCP - 1 in pediatric patients with hydronephrosis has higher clinical significance, and it can assist to judge the kidney functions of patients.