唑来膦酸联合放射治疗对非小细胞肺癌骨转移患者癌痛的疗效观察

目的 探讨唑来膦酸联合放疗在非小细胞肺癌（NSCLC）骨转移患者癌痛治疗中的近期疗效及影响因素。方法 将本院2013年5月至2015年5月收治的106例NSCLC骨转移患者随机分为联合组与对照组（n=53），对照组接受单纯放疗，联合组在放疗基础上联合唑来膦酸治疗。比较两组患者的疼痛缓解情况，采用多因素Logistic回归分析影响患者短期骨痛缓解情况的因素，单因素Logistic回归分析两种治疗方式下影响患者短期骨痛缓解的因素。结果 联合组癌痛缓解有效率为92.5%（49/53）， 高于对照组的69.8%（37/53），差异有统计学意义（P=0.003）；多因素Logistic回归分析显示治疗方式是影响NSCLC骨转移骨痛缓解情况的独立因素，差异有统计学意义（P<0.05）；单因素Logistic回归分析显示联合组CT影像学表现为溶骨性病灶者的治疗效果优于对照组，且其骨相关事件发生率也低于对照组，差异有统计学意义（P<0.05）。结论 唑来膦酸联合放射治疗NSCLC骨转移患者癌痛方面有较好疗效，值得临床推广。

Effect observation of non-small cell lung cancer with osseous metastasis through zoledronic acid combined with radiotherapy

Objective To explore the short-term curative effect and influencing factors of non-small cell lung cancer ( NSCLC) with osseous metastasis through zoledronic acid combined with radiotherapy. Methods In this study, 106 NSCLC patients with osseous metastasis in our hospital from May 2013 to May 2015 were randomly divided into the combination group and the control group with 53 cases in each group. The control group received radiotherapy alone, and the combination group were treated with zole-dronic acid on the basis of radiotherapy. The pain relief statuses of two groups were compared. The factors influencing the short-term pain relief were analyzed using multivariate Logistic regression analysis. The factors influencing the short-term pain relief of two kinds of treatment methods were analyzed using univariate Logistic regression analysis. Results The effective rate of combination group was 92. 5% (49/53), higher than 69. 8% (37/53) of control group (P=0. 003). Multivariate Logistic regression analysis showed that treatment was the independent factor affecting the relief of bone pain in NSCLC with bone metastasis, and the difference was statistically significant ( P<0. 05) . The univariate Logistic regression analysis showed that patients with CT imaging manifestations of osteolytic le-sions in combination group had a better curative effect than in the control group, and the incidence of skeletal-related events was also lower in combination group than the control group ( P<0. 05 ) . Conclusion Zoledronic acid in combination with radiotherapy has better clinical curative effect in treatment of NSCLC with osseous metastasis, worth promoting on clinical.