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Utility of screening for other causes of infertility in women with "known" polycystic ovary syndrome |
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| Authors: | McGovern Peter G,Legro Richard S,Myers Evan R,Barnhart Huiman X,Carson Sandra A,Diamond Michael P,Carr Bruce R,Schlaff William D,Coutifaris Christos,Steinkampf Michael P,Nestler John E,Gosman Gabey,Leppert Phyllis C,Giudice Linda C National Institutes for Child Health Human Development-Reproductive Medicine Network |
| Affiliation: | a Department of Obstetrics, Gynecology and Women’s Health, UMDNJ-New Jersey Medical School, Newark, New Jersey b Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, Pennsylvania c Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina d Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina e Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas f Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan g Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas h Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado i Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania j Department of Obstetrics and Gynecology, University of Alabama, Birmingham, Alabama k Department of Medicine, Virginia Commonwealth University School of Medicine l Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania m Reproductive Sciences Branch, National Institute of Child Health and Human Development, Bethesda, Maryland n Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California |
| Abstract: | We investigated the prevalence of abnormal screening results (questionnaire and testing for other causes of oligo-ovulation, male or tubal factor infertility) in a group of 1,313 oligo-ovulatory women (included and excluded subjects) whose condition was screened for inclusion in the Pregnancy in Polycystic Ovary Syndrome trial, a multicenter clinical trial that was conducted at 13 sites in the United States. Other than failure to demonstrate laboratory evidence of hyperandrogenemia, the most common reasons for subject exclusion were persistent oligospermia and tubal factor infertility. |
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