GONADOTROPIN-RELEASING HORMONE (LH-RH) AND HUMAN CHORIONIC GONADOTROPIN IN THE TREATMENT OF TWO BOYS WITH HYPOGONADOTROPHIC HYPOGONADISM |
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| Authors: | S. KRABBE,N. E. SKAKKEBÆ K |
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| Affiliation: | Childrens Hospital, Fuglebakken, University Department of Paediatrics, Rigshospitalet, Copenhagen, Denmark;Laboratory of Reproductive Biology, University Department of Obstetrics &Gynaecology, Rigshospitalet, Copenhagen, Denmark |
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| Abstract: | ![]()
Abstract. Two brothers, 16 and 14 years of age, with hypogonadotrophic hypogonadism and anosmia were treated with subcutaneous injections of 200μg gonadotropin-releasing hormone at 8-hour intervals for 4 weeks. Serum FSH increased to the range of normal adult men, but serum LH and serum testosterone showed little change and no clinical signs of pubertal development occurred. Thereafter the 2 patients were given HCG for 11 months and a combination of HCG and HMG for a further 3 months. In response to this treatment, the serum testosterone levels increased to the range of normal adult men and a marked development of the secondary sex characteristics was seen. |
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| Keywords: | Male hypogonadotrophic hypogonadism gonadotropin-releasing hormone human chorionic gonadotropin |
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