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PHENOTYPING OF INDIVIDUALS SENSITIVE TO SUXAMETHONIUM: The Cholinesterase Research Unit at the Royal Postgraduate Medical School |
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| Authors: | WHITTAKER, M. BRITTEN, J. J. |
| Affiliation: | Department of Chemistry, University of Exeter Exeter EX4 4QD. Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital London W12 OHS. |
| Abstract: | Four hundred and thirty blood samples from suxamethonium-sensitiveindividuals have been phenotyped by the Cholinesterase ResearchUnit following its transfer from Exeter to the Hammersmith Hospital.The distribution of genotypes has been shown to be similar tothat found in Exeter. Screening for the  and  genes has not yielded any major differences in the gene frequencies ofsensitive individuals, even during pregnancy. The uneven sexdistribution of the patients, as well as other unusual pointsthat have arisen, are discussed. A new gene for the biosynthesisof cholinesterase has probably been identified. |
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