广州地区生殖系统念珠菌病的菌型及其体外药敏结果分析

目的:监测2013年至2019年广州地区生殖系统念珠菌分离菌株情况，及其7种抗真菌药物的敏感性趋势。方法:选取2013年1月至2019年12月期间在广州市皮肤病防治所性传播疾病门诊就诊的生殖系统念珠菌病患者共649例，其中男116例，女533例，年龄15～84岁。采用法国梅里埃公司的ATB ID32C酵母菌鉴定反应板鉴...

Detection of bacterial types and antibiotic susceptivity of genital Candidiasis in Guangzhou

Objective　To monitor the isolates of genital Candidiasis in Guangzhou from 2013 to2019, and to evaluate the susceptibilities of 7 antibioitics. Methods　Six hundred and forty-nine patients with genitalCandidiasis infection treated at Clinic of Sexually Transmitted Diseases,Guangzhou Institute of Dermatology from January 2013 to December 2019 wereselected, including 116 males and 533 females, and they were 15-84 years old.The ATB ID32C bioMerieux France and Rosco Disk diffusion method was be used todo the typing and drug sensitivity test of Candidiasis. The susceptibilitiesfor all kinds of Candidasis were compared. Results　Among the 649 strains of genital Candidiasis, there were 517 strains ofcandida albicans (79.66%), 72 strains of candida glabrata (11.09%), 33 strainsof candida parapsilosis (5.09%), and 27 strains of other Candidiasis (4.16%).The isolatation rate of candida albicans during these 7 years did not changedobviously (χ²=11.56, P>0.05), that of  candida glabrata increased (χ²=13.72, P<0.05), and those of candidaparapsilosis and other candida decreased (χ²=19.28and 14.76,both P<0.05). Thesusceptibilities of genital candida to nystatin, ketoconazole, fluconazole,itraconazole, miconazole, and terbinafine were 99.69% (647/649), 85.20%(553/649), 72.57% (471/649), 52.23% (339/649), 34.36% (223/649), 34.98%(227/649), and 8.32% (54/649). Conclusions　The genital Candidiasis is candida albicans. Candidiasis has a highdrug-susceptibility rate to polyene antibiotics, and is resistant againstazoles. Different kinds of Candidiasis have different antibiotic sensitivities.