首页 | 本学科首页   官方微博 | 高级检索  
     


Long term radiological features of radiation-induced lung damage
Authors:Catarina Veiga  David Landau  Jamie R. McClelland  Jonathan A. Ledermann  David Hawkes  Sam M. Janes  Anand Devaraj
Affiliation:1. Centre for Medical Image Computing, Department of Medical Physics & Biomedical Engineering, University College London, London, UK;2. Department of Oncology, Guy''s & St. Thomas'' NHS Trust, London, UK;3. Department of Oncology, University College London Hospital, London, UK;4. Cancer Research UK and UCL Cancer Trials Centre, UCL Cancer Institute, London, UK;5. Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK;6. Department of Radiology, Royal Brompton Hospital, London, UK
Abstract:

Purpose

To describe the radiological findings of radiation-induced lung damage (RILD) present on CT imaging of lung cancer patients 12?months after radical chemoradiation.

Material and methods

Baseline and 12-month CT scans of 33 patients were reviewed from a phase I/II clinical trial of isotoxic chemoradiation (IDEAL CRT). CT findings were scored in three categories derived from eleven sub-categories: (1) parenchymal change, defined as the presence of consolidation, ground-glass opacities (GGOs), traction bronchiectasis and/or reticulation; (2) lung volume reduction, identified through reduction in lung height and/or distortions in fissures, diaphragm, anterior junction line and major airways anatomy, and (3) pleural changes, either thickening and/or effusion.

Results

Six patients were excluded from the analysis due to anatomical changes caused by partial lung collapse and abscess. All remaining 27 patients had radiological evidence of lung damage. The three categories, parenchymal change, shrinkage and pleural change were present in 100%, 96% and 82% respectively. All patients had at least two categories of change present and 72% all three. GGOs, reticulation and traction bronchiectasis were present in 44%, 52% and 37% of patients.

Conclusions

Parenchymal change, lung shrinkage and pleural change are present in a high proportion of patients and are frequently identified in RILD. GGOs, reticulation and traction bronchiectasis are common at 12?months but not diagnostic.
Keywords:Lung  Radiation-induced lung damage  Computed tomography  Fibrosis
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号