Lysine triggers apoptosis through a NADPH oxidase-dependent mechanism in human renal tubular cells |
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| Authors: | Verzola Daniela Famà Annamaria Villaggio Barbara Di Rocco Maia Simonato Alchiede D'Amato Elena Gianiorio Fabio Garibotto Giacomo |
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| Affiliation: | Department of Internal Medicine, Nephrology Division, Genoa University, IRCSS Azienda Ospedaliera Universitaria San Martino - IST, Viale Benedetto XV,6, 16132, Genoa, Italy. |
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| Abstract: | ![]()
Progressive chronic kidney disease (CKD) is common in lysinuric protein intolerance (LPI), a primary inherited aminoaciduria characterized by massive Lysine excretion in urine. However, by which mechanisms Lysine may cause kidney damage to tubule cells is still not understood. This study determined whether Lysine overloading of human proximal tubular cells (HK-2) in culture enhances apoptotic cell loss and its associated mechanisms. Overloading HK-2 with Lysine levels reproducing those observed in urine of patients affected by LPI (10?mM) increased apoptosis (+30%; p?
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