肾脑复元汤治疗缺血性中风临床疗效及对血液流变学的影响

目的:观察肾脑复元汤治疗缺血性中风的临床疗效,并探讨其对血液流变学的影响。方法:将符合本研究诊断及纳入标准的96例患者采用随机数字表法分为对照组和治疗组,对照组给予西医常规治疗,治疗组在常规治疗的基础上口服肾脑复元汤,分别于治疗前、治疗2,4周后观察两组患者临床神经功能缺损程度评分(CSS),日常生活活动能力量表评分(ADL),中医证候积分及血液流变学参数,评估临床疗效。结果:治疗2,4周后,治疗组CSS评分、中医证候积分、血液流变学参数均显著优于对照组(P0.01);治疗2周后治疗组ADL评分升高,且明显高于对照组(P0.05),治疗4周后治疗组ADL评分显著高于对照组(P0.01)。治疗组临床疗效显著优于对照组(P0.01)。两组患者治疗前安全性指标与治疗后比较均无统计学差异。结论:肾脑复元汤能显著改善缺血性中风患者神经功能,增强生活自理能力,提高临床疗效,同时降低血液黏度,增加血液流动性,且安全性高。

Clinical Efficacy of Shennao Fuyuan Decoction in Treatment of Ischemic Stroke and Effect on Hemorheology

Objective: To investigate the clinical efficacy of Shennao Fuyuan decoction in treatment of ischemic stroke andobserve its effect on hemorheology. Method: According to the diagnostic criteria and inclusion criteria, 96 patients were divided into experimental group and control group with random number table. Patients in control group received conventional western medicine treatment, and patients in experimental group received Shennao Fuyuan decoction on the basis of treatment in control group. Chinese stroke scale(CSS) scores,activities of daily living(ADL) scores, traditional Chinese medicine(TCM) symptom scale scores, clinical efficacy and hemorheology indexes were observed before treatment, 2 weeks and 4 weeks after treatment. Result: After treatment for 2 and 4 weeks, CSS scores, TCM symptom scale scores and hemorheology indexes in experimental group were obviously better than those in control group (P<0.01). After treatment for 2 weeks, ADL scores in treatment group were increased and significantly higher than those in control group(P<0.05), and were extremely significantly higher than control group after treatment for 4 weeks (P<0.01). Clinical efficacy in experimental group was significantly better than that in control group after treatment(P<0.01), and there were no statistical differences in safety indexes between the parameters before and after treatment. Conclusion: Shennao Fuyuan decoction can significantly improve the neurological function, the ability of daily living and clinical efficacy, reduce blood viscosity, and enhance their blood fluidity with high safety in patients with ischemic stroke.