| 长期高脂饲养大鼠骨骼肌musclin表达上调及其与胰岛素抵抗的相关性 |
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| 引用本文： | 曹玲玲,袁莉,徐江祥,刘志强,王霞,张贝,邱海燕,徐国玲,唐兆生.长期高脂饲养大鼠骨骼肌musclin表达上调及其与胰岛素抵抗的相关性[J].中华内分泌代谢杂志,2009,25(2). |
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| 作者姓名： | 曹玲玲 袁莉 徐江祥 刘志强 王霞 张贝 邱海燕 徐国玲 唐兆生 |
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| 作者单位： | 1. 九江市第一人民医院干部病房,332000
2. 华中科技大学附属协和医院内分泌科 |
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| 摘 要： | 研究高脂饮食状态下Wistar大鼠骨骼肌中musclin基因表达及其与胰岛素抵抗以及糖尿病、葡萄糖转运蛋白4(GLUT-4)等的关系,结果 提示muselin的表达增加(1.39±0.36 vs 0.31±O.07,P<0.01)可能与胰岛素抵抗有关,有可能是胰岛素抵抗、糖尿病的一个前期信号,其作用可能与GLUT-4(1.27±O.32 vs 1.84±0.24.P
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| 关 键 词： | 胰岛素抵抗 葡萄糖转运子-4 基因表达 |
Musclin gene overexpression in skeletal muscle of rats with long-term high-fat diet and its correlation with insulin resistance |
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| CAO Ling-ling,YUAN Li,XU Jiang-xiang,LIU Zhi-qiang,WANG Xia,ZHANG Bei,QIU Hai-yan,XU Guo-ling,TANG Zhao-sheng.Musclin gene overexpression in skeletal muscle of rats with long-term high-fat diet and its correlation with insulin resistance[J].Chinese Journal of Endocrinology and Metabolism,2009,25(2). |
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| Authors: | CAO Ling-ling YUAN Li XU Jiang-xiang LIU Zhi-qiang WANG Xia ZHANG Bei QIU Hai-yan XU Guo-ling TANG Zhao-sheng |
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| Abstract: | The expression of musclin gene in skeletal muscle of rats fed with high-fat diet and its correlation to insulin resistance.diabetes mellitus and GLUT4 were explored.The results showed that musclin expressin was up-regulated(1.39±0.36 vs 0.31±0.07,P<0.01)in skeletal muscle of rats fed with high-fat diet, suggesting that this finding may be related with insulin resistance and involvement of GLUT-4 expression(1.27 4± 0.32 vs 1.84±0.24.P<0.01). |
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| Keywords: | Musclin |
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