乌灵胶囊预防脑梗死后抑郁及认知障碍患者疗效观察

目的观察乌灵胶囊(WL)预防腩梗死后抑郁和认知障碍患者临床疗效。方法脑梗死患者435例随机分为WL组和对照组,在常规治疗基础上,WL组口服WL胶囊3粒,每日3次;对照组口服安慰剂胶囊3粒,每日3次,疗程均6周。分别于治疗前及治疗后1、2、4、6周末及3月末以HAMD、MoCA、NIHSS评分进行评定,并观察抑郁发生情况。结果(1)抑郁发病率:治疗2、4周末,WL组抑郁发病率均低于对照组,但差异无统计学意义(P>0.05),治疗6周末及3个月末,WL组抑郁发病率均低于对照组,且差异有统计学意义(P<0.05)。(2)HAMD评分:2组治疗后均较治疗前升高(P<0.05)-,且WL.组2、4、6周末及3个月末均低于对照组(P<0.05)。(3)NIHSS评分:除第1周末外,2组治疗后NIHSS评分均较治疗前下降(P<0.05),且WL组均优于对照组(P<0.05)。(4)MoCA评分:2组治疗后4、5周未及3个月末MoCA评分均较治疗前升高(P<0.05),且WL组均高于对照组(P<0.05)。(5)不良反应:2组均未发生严重不良反应。结论乌灵胶囊防治脑梗死后抑郁及认知障碍疗效明显。

Therapeutic effects of Wuling capsule on the prevention of depression after stroke and cognitive disorder

Objective To observe the curative effects of Witling capsule（WL） in preventing depression after cerebral infarction（DCI） and cognitive disorder.Methods Cerebral infarction 435 cases were randomly divided into two groups（WL group and control group）,based on the conventional treatment,WL group received oral WL capsules,3 times a day;the control group was treated with placebo capsules,3 times daily for all six weeks.Before and after treatment with 1st,2nd,4th,6lh weekends and at the end of 3 months,HAMD,MoCA,NIHSS score were assessed and observed the occurrence of depression.Results（1） The incidence of depression：Treatment at 2nd,4th weekend,incidence rates of depression in WL group were lower than the control group,but the difference was not statistically significant（P 0.05）,and 6 weeks to 3months after treatment,incidence rates of depression in WL group lower than the control group,and the difference was statistically significant（P 0.05）.（2）HAMD score：2 groups after treatment increased than before treatment（P 0.05）,and in the WL group,at 2nd,4th,6th weekend and at the end of 3 months,the score were lower than the control group（P 0.05）.（3） NIHSS score：In addition to the first weekend,after treatment,the two groups＇ NIHSS score decreased than before treatment（P 0.05）,and WL groups were better than the control group（P 0.05）.（4） MoCA Rating;after treatment,at 4th,5th weekend and at the end of 3 months,the 2 groups＇ MoCA scores were elevated before treatment（P 0.05）,and WL groups were higher（P 0.05）.（5） Adverse reactions;two groups were not found serious adverse reactions.Conclusion It showed obviously effect of Willing capsule on preventing DCI and neurological deficit.