Primary central nervous system lymphoma with systemic metastasis: Case report and review |
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| Authors: | Mark T Brown Roger E Mc Clendon Jon P Gockerman |
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| Institution: | (1) Divisions of Neurology, Duke University Medical Center, 27710 Durham, North Carolina, USA;(2) Hematology-Oncology, Duke University Medical Center, 27710 Durham, North Carolina, USA;(3) Department of Medicine & Department of Pathology, Duke University Medical Center, 27710 Durham, North Carolina, USA;(4) Neuro-Oncology Section, Duke University Medical Center, Box 3963, 27710 Durham, NC, USA |
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| Abstract: | Summary Primary central nervous system lymphoma (PCNSL) almost always remains confined to the nervous system. We report a patient with well documented PCNSL who responded to treatment, but subsequently developed pathologically confirmed systemic metastases without repeated local failure 35 months after initial diagnosis. In a review of the world's literature we identified 5 other cases of PCNSL with histologically confirmed antemortem systemic metastases and a total of 62 cases of central nervous system (CNS) lymphoma in some way associated with extraneural lymphoma. These cases are classified and discussed. Clinicians caring for PCNSL patients must remain alert to the possibility of systemic metastasis, especially as local control of PCNSL improves. |
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| Keywords: | primary CNS brain lymphoma systemic metastasis |
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