| 原发性肾病综合征患儿血CD_(30)阳性细胞和IL-6、IL-10的变化及其临床意义 |
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| 引用本文： | 康国贵,周江瑾,丁薇莎,张琦,康友群,陈惠琴,郭立中. 原发性肾病综合征患儿血CD_(30)阳性细胞和IL-6、IL-10的变化及其临床意义[J]. 浙江医学, 2008, 30(11) |
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| 作者姓名： | 康国贵 周江瑾 丁薇莎 张琦 康友群 陈惠琴 郭立中 |
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| 作者单位： | 宁波市妇女儿童医院儿科,315012 |
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| 基金项目： | 宁渡市科技局项目 |
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| 摘 要： | 目的探讨原发性肾病综合征（PNS）患儿血CD30阳性细胞和IL-6、IL-10的变化及其临床意义。方法将56例初发的单纯性PNS患儿根据泼尼松足量、中程疗法治疗8周内尿蛋白是否转阴分为激素敏感组和非激素敏感组,同时另选20例健康儿童作为对照组,分别检测外周血单个核细胞（PBMC）中CD30阳性细胞百分率及PBMC培养上清液中IL-6、IL-10的浓度。结果激素敏感组活动期患儿CD30阳性细胞百分率、IL-6和IL-10浓度均显著高于对照组（均P〈0.01）;激素敏感组缓解期和激素非敏感组患儿各指标与对照组比较差异均无统计学意义（均P〉0.05）。结论CD30阳性细胞和IL-6、IL-10可能在激素敏感性PNS发病中具有一定的作用;在PNS治疗前和治疗中,适时检测CD30阳性细胞和IL-6、IL-10水平可能对预测激素疗效及调整治疗方案具有重要意义。
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| 关 键 词： | 原发性肾病综合征 CD30阳性细胞 |
Changes of blood CD30+cell and IL-6,IL-10 levels in children with primary nephrotic syndrome and their clinical significance |
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| KANG Guogui,ZHOU Jiangjin,DING Weisha,et al.. Changes of blood CD30+cell and IL-6,IL-10 levels in children with primary nephrotic syndrome and their clinical significance[J]. Zhejiang Medical Journal, 2008, 30(11) |
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| Authors: | KANG Guogui ZHOU Jiangjin DING Weisha et al. |
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| Affiliation: | KANG Guogui,ZHOU Jiangjin,DING Weisha,et al.Department of Pediatrics,Ningbo Women , Children's Hospital,Ningbo 315012,China |
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| Abstract: | Objective To investigate the changes and clinical significance of blood CD30+cell and interleukin-6 (IL-6),interleukin-10(IL-10)levels in children with primary nephrotic syndrome(PNS).Methods Fifty six PNS patients were divided into two groups(steroid sensitive group and steroid resistive group)according to positive or negative proteinuria after orally taking prednisone in 8 weeks.Twenty healthy children were served as the control group.The percentage of CD30+ cells and levels of IL-6,IL-10 in peripheral bl... |
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| Keywords: | IL-6 IL-10 |
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