The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney,and alteration by furosemide |
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| Authors: | Ayberk Besen Fatih Kose Saime Paydas Gulfiliz Gonlusen Tamer Inal Ayse Dogan Mustafa Kibar Mustafa Balal |
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| Affiliation: | (1) Faculty of Medicine, Department of Nephrology, Cukurova University, Adana, Turkey;(2) Faculty of Medicine, Department of Pathology, Cukurova University, Adana, Turkey;(3) Faculty of Medicine, Department of Biochemistry, Cukurova University, Adana, Turkey;(4) Faculty of Medicine, Department of Physiology, Cukurova University, Adana, Turkey;(5) Faculty of Medicine, Department of Nuclear Medicine, Cukurova University, Adana, Turkey; |
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| Abstract: | ![]()
Introduction Renal physiology is a partially cyclooxygenase (COX)-dependent system. Kidneys express both COX-1 and COX-2 enzymes. In this study, we tried to investigate the effects of diclofenac sodium (D), with or without furosemide (F), on plasma renin activity (PRA), serum and urine electrolytes, creatinine clearance, and COX-1 and COX-2 expression in the renal cortex. |
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