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淋巴管内皮细胞透明质酸受体-1在发育小鼠肾内的表达
引用本文:秦燕霞,徐蕴,霍冠华. 淋巴管内皮细胞透明质酸受体-1在发育小鼠肾内的表达[J]. 解剖学杂志, 2010, 33(1)
作者姓名:秦燕霞  徐蕴  霍冠华
作者单位:1. 济宁医学院人体解剖学教研室,日照,276820
2. 滨州医学院组织学与胚胎学教研室,烟台,264000
摘    要:目的:探讨淋巴管内皮细胞透明质酸受体-1(LYVE-1)在发育小鼠肾内的表达.方法:胚胎期第13~18天(E13~18)的胎鼠和出生后第4、 14和21天(P4~21)及成年小鼠的肾,行LYVE-1免疫组织化学显色.结果:LYVE-1免疫阳性淋巴管丛最早在胚胎期第14天的小鼠肾检测到,主要位于肾皮质的动脉周围.在胚胎期第15天的肾小球中最早检测到LYVE-1免疫阳性细胞,但LYVE-1免疫阳性细胞在肾小球中的数量和位置不定.结论:LYVE-1免疫阳性细胞主要位于肾动脉周围淋巴管,在肾小球中也有LYVE-1表达.

关 键 词:淋巴管内皮细胞透明质酸受体-1  淋巴管    小鼠

Expression of lymphatic endothelium specific hyaluronan receptor-1 in the developing mouse kidney
Qin Yanxia,Xu Yun,Huo Guanhua. Expression of lymphatic endothelium specific hyaluronan receptor-1 in the developing mouse kidney[J]. Chinese Journal of Anatomy, 2010, 33(1)
Authors:Qin Yanxia  Xu Yun  Huo Guanhua
Abstract:Objective: To investigate the expression of lymphatic endothelium specific hyaluronan receptor-1 (LYVE-1) in developing mouse kidney. Methods: The mouse kidneys from embryonic day 13 (E13) to E18, from postnatal day 4 (P4) to P21 and from adults were sectioned, and then LYVE-1 expression was immunostained. Results: LYVE-1~+ lymphatic plexus was first detected in the mouse kidneys at E14 stage. From E14 onward, LYVE-1~+ lymphatic vessels were distributed along the arteries in the cortex. LYVE-1~+ cells first appeared in the glomerulars at E15 but the number and location was uncertain. Conclusion: LYVE-1~+ lymphatic vessels are distributed along the arteries and LYVE-1~+cells could be detected in the glomerulus.
Keywords:lymphatic endothelium specific hyaluronan receptor-1  lymphatic vessels  kidney  mouse
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