HBV endemicity in Mexico is associated with HBV genotypes H and G |
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作者姓名: | Sonia Roman Arturo Panduro |
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作者单位: | Department of Molecular Biology in Medicine,Civil Hospital of Guadalajara,"Fray Antonio Alcalde",and Health Sciences Center,University of Guadalajara |
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基金项目: | Supported by National Council of Science and Technology(CONACYT-FONDO SECTORIAL,Mexico),Grant No.Salud-2010-1-139085,to Roman S;Jalisco State Council of Science and Technology(COECYTJAL-Universidad de Guadalajara,Guadalajara,Jalisco,Mexico),Grant No.2009-1-06-2009-431,to Panduro A |
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摘 要: | Hepatitis B virus(HBV)genotypes have distinct genetic and geographic diversity and may be associated with specific clinical characteristics,progression,severity of disease and antiviral response.Herein,we provide an updated overview of the endemicity of HBV genotypes H and G in Mexico.HBV genotype H is predominant among the Mexican population,but not in Central America.Its geographic distribution is related to a typical endemicity among the Mexicans which is characterized by a low hepatitis B surface antigen seroprevalence,apparently due to a rapid resolution of the infection,low viral loads and a high prevalence of occult B infection.During chronic infections,genotype H is detected in mixtures with other HBV genotypes and associated with other co-morbidities,such as obesity,alcoholism and co-infection with hepatitis C virus or human immunodeficiency virus.Hepatocellular carcinoma prevalence is low.Thus,antiviral therapy may differ significantly from the standard guidelines established worldwide.The high prevalence of HBV genotype G in the Americas,especially among the Mexican population,raises new questions regarding its geographic origin that will require further investigation.
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关 键 词: | Hepatitis B virus genotypes Hepatitis B virus genotype H Hepatitis B virus genotype G Molecular epidemiology Mexico Antiviral therapy Severity of liver disease Clinical outcome |
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