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| 药物性消化道系统损伤标志物及其评价 | |
| 引用本文： | 马红,刘淑清,杨凌. 药物性消化道系统损伤标志物及其评价[J]. 世界中医药, 2020, 15(23) |
| 作者姓名： | 马红 刘淑清 杨凌 |
| 作者单位： | 上海市针灸经络研究所,上海,200030;大连医科大学基础医学院生物化学系,大连,116044;大连医科大学基础医学院生物化学系,大连,116044;上海中医药大学交叉科学研究院,上海,201203 |
| 基金项目： | 国家重点研发计划项目(2017YFC1702000，2020YFC0845400);国家重大专项“重大新药创制”项目(2018ZX09731016-004);国家自然科学基金项目(81803489,81703604,81903576,81773810) |
| 摘 要： | 消化道是体内多脏器的管状组合,在体内组成、结构、功能复杂,在受到损伤时也表现出的不同特征。药物导致的消化道损伤因损伤发生的具体部位、细胞种类、损伤程度、标志物类型而异。组织、细胞标志性酶活性评价是表征消化道损伤最简单有效的方法。但是,这些标志物常常会因体内基础疾病导致的代谢紊乱而发生变化,进而影响损伤评价的准确性。只有深刻了解损伤机制,才能做到消化道损伤的准确与稳定性评价。本文综述了消化道的组成、结构、以及因代谢紊乱诱发损伤标志物变化对损伤评价产生的影响。 |
| 关 键 词： | 消化道损伤 生物标志物 代谢酶 转运体 |
| 收稿时间： | 2020-11-19 |
Biomarkers and Assessments of Drug-induced Digestive Tract Injures |
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| MA Hong,LIU Shuqing,YANG Ling. Biomarkers and Assessments of Drug-induced Digestive Tract Injures[J]. World Chinese Medicine, 2020, 15(23) | |
| Authors: | MA Hong LIU Shuqing YANG Ling |
| Affiliation: | 1 Shanghai Research Institute of Acupuncture and Meridian,Shanghai 200030,China; 2 Department of Biochemistry,College of Basic Medical Sciences,Dalian Medical University,Dalian 116044,China; 3 Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China |
| Abstract: | The digestive tract is a tubular combination of multiple organs in the body,with complex composition,structure and function,and different characteristics in case of injury.The injury of digestive tract caused by drugs varies with the specific site,cell types,damage degree and marker types.Evaluation of tissue and cell marker enzyme activity is the simplest and most effective way to characterize the damage of the digestive tract.However,these markers are often changed due to metabolic disorders caused by in vivo underlying diseases,thus affecting the accuracy of injury assessment.Only by deeply understanding the injury mechanism can we achieve the accurate and stable evaluation of digestive tract injury.This paper reviews the composition and structure of digestive tract,and the impact of changes in injury markers induced by metabolic disorders on injury evaluation. |
| Keywords: | Digestive tract injure Biomarker Metabolic enzyme Transporter |
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