淋巴细胞、C反应蛋白联合外周血中性粒细胞淋巴细胞比值检测在新型冠状病毒肺炎早期诊断中的应用价值

目的探讨中性粒细胞淋巴细胞比值（NLR）、淋巴细胞（LY）和C反应蛋白（CRP）单独与联合检测在新型冠状病毒肺炎（COVID-19）早期诊断中的临床应用价值。方法选取对53例COVID-19病人（COVID-19组）以及同期90例其他呼吸系统疾病病人（对照组），回顾性分析和比较2组病人中性粒细胞淋巴细胞比值（NLR）、淋巴细胞（LY）和C反应蛋白（CRP）的表达水平。并利用ROC曲线分析NLR、LY、CRP单独以及NLR+LY+CRP联合检测对COVID-19的早期诊断价值。结果COVID-19组NLR、CRP水平均高于对照组，LY水平低于对照组（P < 0.01）。NLR、LY、CRP单独及联合用于COVID-19感染诊断的ROC曲线下面积分别为0.610、0.705、0.833、0.817；灵敏度分别为31.0%、69.8%、67.9%、58.5%；特异度分别为96.7%、62.2%、80.0%、92.2%，NLR+LY+CRP联合诊断的价值高于单独诊断价值。结论NLR、LY、CRP联合诊断可以提高COVID-19早期诊断的特异度和灵敏度，从而指导临床尽早采取合理治疗措施，提高COVID-19的治愈率。

Value of lymphocyte,C reactive protein combined with peripheral blood neutrophil to lymphocyte ratio in the early diagnosis of COVID-19

ObjectiveTo investigate the clinical application value of the single and combined detection of the neutrophil to lymphocyte ratio(NLR), lymphocyte(LY) and C reactive protein(CRP) in the early diagnosis of corona virus disease 2019(COVID-19).MethodsFifty-three patients with COVID-19 and 90 patients with other respiratory diseases were divided into the COVID-19 group and control group, respectively.The levels of NLR, LY and CRP between two groups were retrospectively analyzed and compared.The ROC curve was used to analyze the application value of the single and combined detection of NLR, LY and CRP in the early diagnosis of COVID-19.ResultsThe levels of NLR and CRP in COVID-19 group were higher than those in control group, and the level of LY in COVID-19 group was significantly lower than that in control group(P < 0.01).The area under the ROC curve of the single and combined detection of NLR, LY and CRP in the diagnosis of COVID-19 were 0.610, 0.705, 0.833 and 0.817, respectively.The sensitivities and specificities of the single and combined detection of NLR, LY and CRP in the diagnosis of COVID-19 were 31.0%, 69.8%, 67.9%, 58.5% and 96.7%, 62.2%, 80.0%, 92.2%, respectively.The diagnosis value of the combined detection of NLR, LY and CRP were higher than that of the single detection of NLR, LY and CRP.ConclusionsThe combined detection of NLR, LY and CRP can increase the specificity and sensitivity of early diagnosis of COVID-19, which can guide the clinical treatment as soon as possible, and improve the cure rate of COVID-19.