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| 含胱天蛋白酶富集功能域凋亡抑制因子在心血管疾病中的研究进展 | |
| 引用本文： | 李奇,杨俊,杨简,杨英. 含胱天蛋白酶富集功能域凋亡抑制因子在心血管疾病中的研究进展[J]. 中国医学科学院学报, 2019, 41(4): 536-540. DOI: 10.3881/j.issn.1000-503X.10900 |
| 作者姓名： | 李奇 杨俊 杨简 杨英 |
| 作者单位： | 三峡大学第一临床医学院心内科 心血管病研究所,湖北宜昌 443002 |
| 基金项目： | 国家自然科学基金(81670333);三峡大学学位论文培优基金(2019SSPY100) |
| 摘 要： | 细胞凋亡在维持机体正常发育以及内环境稳定中发挥重要作用,同时也对多种疾病的病理生理产生影响。研究表明心肌细胞凋亡参与了多种心血管疾病的发生发展过程。含胱天蛋白酶富集功能域凋亡抑制因子(ARC)是迄今为止唯一在心脏特异性高表达的抗凋亡蛋白,并可通过其抗凋亡能力发挥心肌保护作用。本文就ARC的结构和特点、ARC在心血管疾病中的作用及机制予以综述。 |
| 关 键 词： | 含胱天蛋白酶富集功能域凋亡抑制因子 凋亡 心血管疾病 |
| 收稿时间： | 2018-10-09 |
Advances in the Apoptosis Repressor with Caspase Recruitment Domain in Cardiovascular Diseases |
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| LI Qi,YANG Jun,YANG Jian,YANG Ying. Advances in the Apoptosis Repressor with Caspase Recruitment Domain in Cardiovascular Diseases[J]. Acta Academiae Medicinae Sinicae, 2019, 41(4): 536-540. DOI: 10.3881/j.issn.1000-503X.10900 | |
| Authors: | LI Qi YANG Jun YANG Jian YANG Ying |
| Affiliation: | Department of Cardiology,Institute of Cardiovascular Diseases,the First College of Clinical Medical Sciences,China Three Gorges University,Yichang,Hubei 443002,China |
| Abstract: | Apoptosis plays important roles in maintaining normal development and homeostasis and in the pathophysiological processes of various diseases.Previous studies have shown that cardiomyocyte apoptosis is involved in the development of various cardiovascular diseases.The apoptosis repressor with caspase recruitment domain(ARC)is abundantly expressed in heart,which makes ARC a unique and central cardioprotective factor via anti-apoptotic pathway.This article reviews the structure and characteristics of ARC as well as the roles and mechanisms of ARC in cardiovascular diseases. |
| Keywords: | apoptosis repressor with caspase recruitment domain apoptosis cardiovascular diseases |
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