非甾体类抗炎药对急性胰腺炎的治疗意义

急性胰腺炎是指多种病因引起的胰酶激活,继以胰腺局部炎性反应为主要特征,伴或不伴有其他器官功能改变的疾病。炎症因子的产生及释放是其发病机制的重要环节。非甾体类抗炎药(NSAIDs)作为最常见的抗炎药物,已被应用于治疗多种炎症性疾病。近年来,诸多研究表明其代表性药物吲哚美辛可预防具有高危因素患者的内镜下逆行胰胆管造影术后胰腺炎;但对于急性胰腺炎患者的治疗作用,尤其是在减轻全身炎症反应及预防器官衰竭方面的作用尚不明确。大部分动物实验显示NSAIDs具有器官保护作用,但现有初步临床研究结果并不一致。大样本随机对照研究将有助于阐明NSAIDs对急性胰腺炎的治疗意义。

Non-steroidal Anti-inflammatory Drugs in the Treatment of Acute Pancreatitis

Acute pancreatitis(AP)is an inflammatory condition of the pancreas following the activationt of pancreatic enzymes induced by a variety of factors,with or without other organ dysfunction.The production and release of inflammatory factors is generally considered as a key link during pathogenesis.Non-steroidal anti-inflammatory drugs(NSAIDs)are the most commonly applied agents for inflammatory diseases.Many studies have proved that indomethacin can reduce the risk of pancreatitis after endoscopic retrograde cholangiopancreatography;however,few high-quality evidences have demonstrated the roles of NSAIDs in treating,rather than preventing AP.Most animal experiments have shown that NSAIDs can protect organs,although the currently available findings remained inconsistent.Randomized controlled trials with large sample sizes are warranted to elucidate the roles of NSAIDs in treating AP.