中国老年期痴呆患病率Meta分析

目的通过Meta分析了解我国老年期痴呆的患病情况。 方法检索1979-2019年中国期刊全文数据库、万方数据库、中国生物医学文献数据库、维普数据库中有关中国老年期痴呆患病率研究文献，以及PubMed数据库中1946-2019年关于中国老年期痴呆患病率的相关文献。根据STROBE声明中针对横断面研究的评价标准进行文献质量评价，利用Stata 12.0软件合并患病率，并对性别、地区、年龄等因素进行亚组分析，采用Egger检验及漏斗图评估各文献发表偏倚，并作敏感性分析。 结果共纳入文献48篇，总样本量165 192例；其中43篇文献报道了不同性别的人数，男70 448例，女81 668例。中国老年期痴呆总患病率为5.3%（95%CI=4.5%-6.0%）。亚组分析结果显示，女性患病率高于男性，文化程度小学及以下患病率高于小学以上，≥70岁年龄组患病率高于60～69岁组，发表年份在2010-2019年的患病率高于1994-2009年，差异均有统计学意义（t=3.051、5.957、10.140、3.554，P<0.05）。不同地区和不同类型居住地的患病率差异无统计学意义（t=1.028、1.042，P>0.05）。 结论我国老年期痴呆总体患病率较高，女性患病率明显高于男性，年龄越大患病率越高，应针对性采取适宜的预防策略加以控制。

Prevalence of dementia in the elderly in China: A systematic review and Meta analysis

ObjectiveTo understand the prevalence of dementia in the elderly in China through Meta analysis. MethodsWe searched the CNKI database, Wanfang database, CBM database and VIP database from 1979 to 2019 about the prevalence of dementia in China, as well as the PubMed database from 1946 to 2019. The literature quality was evaluated according to the evaluation criteria for cross-sectional studies stated by STROBE, the combined prevalence rate was evaluated by Stata 12.0 software. The gender, region, age and other factors were analyzed by subgroup analysis. The publication bias was evaluated by egger test and funnel plot, and the sensitivity was analyzed. ResultsA total of 48 references were included, with a total sample size of 165 192, including 70 448 males and 81 668 females. The overall prevalence of dementia in the elderly in China was 5.3%(95%CI=4.5%-6.0%). The subgroup analysis showed that the prevalence rate of female was higher than that of male, the prevalence of primary school and below was higher than that of above primary school, the prevalence of the aged ≥ 70 years was higher than that of the aged 60~69 years, the prevalence rate of publication year in 2010-2019 was higher than that in 1994-2009, all the differences were statistically significant (t=3.051, 5.957, 10.140, 3.554; P < 0.05). There was no statistically significant difference in the prevalence rate among different regions and different types of residence (t=1.028, 1.042; P > 0.05). ConclusionThe prevalence rate of dementia in the elderly is higher in China, and the prevalence rate of female is significantly higher than that of male, and the prevalence rate increases with age, Therefore, appropriate prevention strategies should be taken to control it.