布拉酵母联合小剂量红霉素对功能性消化不良患儿血清胃动素及胃泌素的影响

目的研究布拉酵母联合小剂量红霉素对功能性消化不良患儿血清胃动素、胃泌素的影响。方法以某医院2017年8月—2018年10月收治的90例功能性消化不良患儿为研究对象,采用随机数字法将所有患儿分为对照组(n=45)、观察组(n=45)。对照组应用小剂量红霉素对患儿进行治疗,观察组在小剂量红霉素的基础上联合布拉酵母治疗。结果观察组恶心、呕吐、嗳气、腹胀及疼痛评分(7.68±1.78)分、(6.42±0.92)分、(8.21±1.25)分、(8.34±1.33)分、(7.24±1.63)分]均低于对照组(10.34±1.09)分、(9.42±1.18)分、(12.71±1.43)分、(13.70±1.36)分、(15.39±1.56)分],差异有统计学意义(P<0.05);观察组治疗后血清胃动素为(281.16±45.81)ng/L、胃泌素为(182.65±16.81)ng/L,高于对照组,总有效率(97.78%)高于对照组,差异均有统计学意义(P<0.05)。结论布拉酵母联合小剂量红霉素对功能性消化不良患儿治愈率显著,与其提高患儿胃动素、胃泌素的水平相关。

Effect of Saccharomyces boulardii combined with low dose erythromycin on serum motilin and gastrin in children with functional dyspepsia

Objective To study the effect of Saccharomyces boulardii combined with low dose erythromycin on serum motilin and gastrin in children with functional dyspepsia. Methods From August 2017 to October 2018, 90 children with functional dyspepsia were randomly divided into a control group (n=45) and a trial group (n=45). The control group was treated with low dose erythromycin, and the trial group was given S. boulardii on the basis of low dose erythromycin. Results The scores of nausea, vomiting, belching, abdominal distension and pain in the trial group (7.68±1.78), (6.42±0.92), (8.21±1.25), (8.34±1.33), (7.24±1.63) were lower than those in the control group , the difference was statistically significant (P<0.05). After the treatment, the serum levels of motilin and gastrin were (281.16±45.81) ng/L and (182.65±16.81) ng/L in the trial group, which were higher than those in the control group, respectively. The total effective rate of the trial group was 97.78%, which was higher than that of the control group (P<0.05). Conclusion The cure rate of the combination of S. boulardii and low dose erythromycin is significant in the treatment of children with functional dyspepsia, which is related to the increase of motilin and gastrin levels of the children.